Non-receptor protein tyrosine kinases.
Non-receptor protein tyrosine kinases.
复制标题
DOI：
10.2741/1106
复制
发表时间：
2003-05
期刊：
影响因子：
--
通讯作者：
A. Tsygankov
中科院分区：
文献类型：
--
作者：
A. Tsygankov
蛋白酪氨酸激酶（PTK）是催化ATP的γ-磷酸基团转移到肽中特定酪氨酸残基的羟基的酶。尽管各种PTK催化的磷酸转移反应在其基本机制方面是相似的，但它们的生物学功能表现出相当程度的特异性。PTK根据跨膜结构域和胞外结构域的存在分为两组。尽管大多数PTK具有这些结构域，这使得它们能够识别细胞外配体，但许多PTK缺乏这些序列，因此被称为非受体或非跨膜PTK。人类基因组中存在32个编码非受体PTK的基因。本文就哺乳动物非受体PTK家族的组成、结构、表达、功能及其调控进行综述。
The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides. Although phosphotransfer reactions catalyzed by various PTKs are similar with regard to their basic mechanisms, their biological functions demonstrate a considerable degree of specificity. PTKs are divided into two groups according to the presence of transmembrane and extracellular domains. Whereas most PTKs possess these domains, which render them capable of recognizing extracellular ligands, many PTKs lack these sequences and are therefore referred to as non-receptor or non-transmembrane PTKs. Thirty-two genes encoding for non-receptor PTKs are present in the human genome. The current review focuses on the composition, structure, expression, functions and regulation of the mammalian non-receptor PTK families.