On utilizing alternating current-flow field effect transistor for flexibly manipulating particles in microfluidics and nanofluidics
On utilizing alternating current-flow field effect transistor for flexibly manipulating particles in microfluidics and nanofluidics
复制标题
利用交流流场效应晶体管灵活操纵微流控和纳流控中的粒子
DOI：
10.1063/1.4949771
复制
发表时间：
2016-05-01
期刊：
影响因子：
3.2
通讯作者：
Ding, Yucheng
中科院分区：
文献类型：
--
作者：
Liu, Weiyu;Shao, Jinyou;Ding, Yucheng
通过对中心金属条施加偏置栅极电压，在该平面栅极电极的表面上发生感应电荷电渗流中的任意对称性破坏，这种现象被称为AC流场效应晶体管（AC-FFET）。在这项工作中，AC-FFET的潜力与可移动的流动停滞线灵活地操纵微纳米粒子样品在静态和连续流动条件下，通过理论分析和实验验证。研究了有限德拜诱导双层长度和外加场频率对静态条件下操纵柔性因子的影响，表明AC-FFET在纳米流体中实现目标纳米颗粒样品位置可控浓缩方面比以前的微流体试验更有效。此外，一个连续的基于微流体的颗粒浓缩器/导向器的开发，以处理在动态条件下的传入的分析物，它利用串联电极配置的设计，以连续地流动聚焦和转移传入的颗粒样品到所需的下游分支通道，作为后续生化分析的先决条件。我们使用AC-FFET的物理演示证明了灵活电动框架的创新设计的价值，由于简单的电极结构，这些框架可以方便地与其他微流体或纳米流体组件集成到完整的芯片实验室诊断平台中。由AIP出版社出版。
By imposing a biased gate voltage to a center metal strip, arbitrary symmetry breaking in induced-charge electroosmotic flow occurs on the surface of this planar gate electrode, a phenomenon termed as AC-flow field effect transistor (AC-FFET). In this work, the potential of AC-FFET with a shiftable flow stagnation line to flexibly manipulate micro-nano particle samples in both a static and continuous flow condition is demonstrated via theoretical analysis and experimental validation. The effect of finite Debye length of induced double-layer and applied field frequency on the manipulating flexibility factor for static condition is investigated, which indicates AC-FFET turns out to be more effective for achieving a position-controllable concentrating of target nano-particle samples in nanofluidics compared to the previous trial in microfluidics. Besides, a continuous microfluidics-based particle concentrator/director is developed to deal with incoming analytes in dynamic condition, which exploits a design of tandem electrode configuration to consecutively flow focus and divert incoming particle samples to a desired downstream branch channel, as prerequisite for a following biochemical analysis. Our physical demonstrations with AC-FFET prove valuable for innovative designs of flexible electrokinetic frameworks, which can be conveniently integrated with other microfluidic or nanofluidic components into a complete lab-on-chip diagnostic platform due to a simple electrode structure. Published by AIP Publishing.