Phenotype of frailty: Characterization in the women's health and aging studies
Phenotype of frailty: Characterization in the women's health and aging studies
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DOI：
10.1093/gerona/61.3.262
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发表时间：
2006-03-01
影响因子：
5.1
通讯作者：
Fried, LP
中科院分区：
文献类型：
--
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
背景。“衰弱”是一种不良的、主要与老年医学相关的健康状况，因其常随衰老出现且具有严重后果而受到关注。尽管临床医生声称极度衰弱很容易识别，但直到最近，衰弱的标准化定义仍难以确定。本文评估了在女性健康与衰老研究（WHAS）中一种离散的衰弱测量方法的交叉效度、效标效度和内部效度，该方法最近在心血管健康研究（CHS）中得到了验证。
方法。在WHAS数据集中描述了在CHS中制定的衰弱测量方法。利用潜在类别分析，我们评估了构成该测量方法的标准是否聚合成一种综合征。我们通过测试被定义为衰弱的参与者是否比其他人更有可能出现不良的老年病结果或死亡，来验证该测量方法的效标效度。
结果。WHAS和CHS中衰弱的分布具有可比性。在潜在类别分析中，这些测量方法相对于将衰弱描述为一种医学综合征的既定理论显示出很强的内部效度。在比例风险模型中，衰弱女性出现日常生活活动（ADL）和/或工具性日常生活活动障碍、住院以及死亡的风险更高，且与多种潜在的混杂因素无关。
结论。本研究的结果与将衰弱概念化为一种综合征的广泛接受的理论一致。在CHS中制定的衰弱定义适用于不同的人群样本，并确定了多种不良结果的高风险特征。
Background. "Frailty" is an adverse, primarily gerontologic. health condition regarded its frequent with aging and having severe consequences. Although clinicians claim that the extremes of frailty can be easily recognized, a standardized definition of frailty has proved elusive until recently. This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure, of frailty recently validated in the Cardiovascular Health Study (CHS).Methods. The frailty measure developed in CHS was delineated in the WHAS data sets. Using latent class analysis, we evaluated whether criteria composing the measure aggregate into a syndrome. We verified the criterion validity of the measure by testing whether participants defined as frail were more likely than others to develop adverse geriatric outcomes or to die.Results. The distributions of frailty in the WHAS and CHS were comparable. In latent class analyses, the measures demonstrated strong internal validity vis a vis stated theory characterizing frailty as a medical syndrome. In proportional hazards models, frail women had a higher risk of developing activities of daily living (ADL) and/or instrumental ADL disability, institutionalization, and death independently of multiple potentially confounding factors. , Conclusions. The findings of this study are consistent with the widely held theory that conceptualizes frailty its a syndrome. The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes.