SINGLE DAY MEFLOQUINE-ARTESUNATE COMBINATION IN THE TREATMENT OF MULTIDRUG-RESISTANT FALCIPARUM-MALARIA
SINGLE DAY MEFLOQUINE-ARTESUNATE COMBINATION IN THE TREATMENT OF MULTIDRUG-RESISTANT FALCIPARUM-MALARIA
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DOI：
10.1016/0035-9203(94)90303-4
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发表时间：
1994-03-01
影响因子：
2.2
通讯作者：
WHITE, NJ
中科院分区：
文献类型：
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作者：
LUXEMBURGER, C;TERKUILE, FO;WHITE, NJ
在泰缅边境多药耐药地区的552例无并发症恶性疟患者中，比较了低剂量甲氟喹（15 mg/kg）加青蒿琥酯（10 mg/kg）每日一次（MA）与目前使用的高剂量甲氟喹（25 mg/kg）（MQ）方案的疗效和毒性。MA提供了更快的临床和寄生虫学反应，并防止了早期治疗失败; MQ组有15名患者（6%）早期失败，
The therapeutic efficacy and toxicity of a combination of low dose mefloquine (15 mg/kg) plus artesunate 10 mg/kg in one day (MA) was compared with the currently used regimen of high dose mefloquine (25 mg/kg) (MQ) in 552 patients with uncomplicated falciparum malaria in an area of multi-drug resistance on the Thai-Burmese border. MA gave faster clinical and parasitological responses and prevented early treatment failure; 15 patients in the MQ group (6%) were early failures (