Association between the triglyceride glucose index and coronary collateralization in coronary artery disease patients with chronic total occlusion lesions.
Association between the triglyceride glucose index and coronary collateralization in coronary artery disease patients with chronic total occlusion lesions.
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DOI：
10.1186/s12944-021-01574-x
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发表时间：
2021-10-25
影响因子：
4.5
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Gao A;Liu J;Hu C;Liu Y;Zhu Y;Han H;Zhou Y;Zhao Y
最近的研究证实了甘油三酯葡萄糖（TyG）指数在预测冠状动脉疾病（CAD）患者预后中的作用，但尚未有相关研究显示在冠状动脉慢性完全闭塞（CTO）事件中TyG指数与冠状动脉侧支化之间的相关性。本研究旨在探讨TyG指数是否与CTO病变的CAD患者的侧支受损相关或相关程度。该研究入组了1093例因至少一处CTO病变接受心导管插入术的CAD患者。数据来源于北京安贞医院病历系统。根据Rentrop分类系统确定侧支循环的程度。TyG指数和冠状动脉侧支化之间的相关性进行了评估。总体而言，318例患者被纳入不发达的侧支化（Rentrop分类0-1）组。侧支受损组TyG指数明显高于对照组（9.3±0.65 vs.8.8 ±0.53，P<0.001）。在调整各种混杂因素后，TyG指数仍然与抵押受损的发生相关，与第一个三分位组相比，T2和T3组的比值比（OR）分别为1.59和5.72（P<0.001）。此外，亚组分析表明，较高的TyG指数值仍然与抵押不发达的风险增加密切相关。为了比较TyG指数和其他代谢异常指标之间形成侧支的风险评估功效，获得了受试者工作特征（ROC）曲线下面积（AUC）。当将TyG指数添加到基线模型中时，受损抵押品的风险评估性能出现了显着改善。增加的TyG指数与CTO病变的CAD患者中不发达的侧支化密切相关，其风险评估性能优于单一代谢异常指标。在线版本包含补充材料，可通过10.1186/s12944-021-01574-x获得。
Recent studies have substantiated the role of the triglyceride glucose (TyG) index in predicting the prognosis of coronary artery disease (CAD) patients, while no relevant studies have revealed the association between the TyG index and coronary collateralization in the event of coronary chronic total occlusion (CTO). The current study intends to explore whether, or to what extent, the TyG index is associated with impaired collateralization in CAD patients with CTO lesions. The study enrolled 1093 CAD patients undergoing cardiac catheterization for at least one CTO lesion. Data were collected from the Beijing Anzhen Hospital record system. The degree of collaterals was determined according to the Rentrop classification system. The correlation between the TyG index and coronary collateralization was assessed. Overall, 318 patients were included in a less developed collateralization (Rentrop classification 0-1) group. The TyG index was significantly higher in patients with impaired collateralization (9.3±0.65 vs. 8.8±0.53, P<0.001). After adjusting for various confounding factors, the TyG index remained correlated with the occurrence of impaired collateralization, with odds ratios (ORs) of 1.59 and 5.72 in the T2 and T3 group compared with the first tertile group (P<0.001). In addition, subgroup analysis showed that higher TyG index values remained strongly associated with increased risk of less developed collateralization. To compare the risk assessment efficacy for the formation of collateralization between the TyG index and other metabolic abnormality indicators, an area under the receiver-operating characteristic (ROC) curve (AUC) was obtained. A significant improvement in the risk assessment performance for impaired collateralization emerged when adding the TyG index into a baseline model. The increased TyG index is strongly associated with less developed collateralization in CAD patients with CTO lesions and its risk assessment performance is better than single metabolic abnormality indicators. The online version contains supplementary material available at 10.1186/s12944-021-01574-x.
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影响因子：
5.2
作者：
Liu R;Guan S;Gao Z;Wang J;Xu J;Hao Z;Zhang Y;Yang S;Guo Z;Yang J;Shao H;Chang B
通讯作者：
Chang B
影响因子：
9.3
作者：
Hu, Chengping;Zhang, Jianwei;Zhao, Yingxin
通讯作者：
Zhao, Yingxin
影响因子：
37.8
作者：
Brilakis, Emmanouil S.;Mashayekhi, Kambis;Rinfret, Stephane
通讯作者：
Rinfret, Stephane
DOI：
10.3390/diagnostics10121081
发表时间：
2020-12-12
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Chiu TH;Huang YC;Chiu H;Wu PY;Chiou HC;Huang JC;Chen SC
通讯作者：
Chen SC
影响因子：
4.6
作者：
Lin HY;Zhang XJ;Liu YM;Geng LY;Guan LY;Li XH
通讯作者：
Li XH