The potential role of positron emission mammography for detection of breast cancer. A phantom study.
The potential role of positron emission mammography for detection of breast cancer. A phantom study.
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DOI：
10.1118/1.1287439
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发表时间：
2000-08
期刊：
影响因子：
3.8
通讯作者：
R. Raylman;Stan Majewski;Randy Wojcik;A. Weisenberger;B. Kross;Vladimir K. Popov;Harry A. Bishop
中科院分区：
文献类型：
--
作者：
R. Raylman;Stan Majewski;Randy Wojcik;A. Weisenberger;B. Kross;Vladimir K. Popov;Harry A. Bishop
正电子发射乳腺X射线摄影（PEM）是一种新的，专门的成像方式，利用PET放射性药物来检测乳腺癌。通过一系列体模实验，研究了PEM检测乳腺肿瘤的能力和局限性。将PEM成像仪安装在标准Lorad活检台上（间隔18 cm）。在调查的初始阶段，测量基本的扫描仪参数（分辨率，灵敏度和散射分数）。然后，利用特殊的体模探索了一些乳腺成像参数（采集长度、乳腺厚度和乳腺密度）对乳腺病变检测的影响。用含有与370 MBq注射量一致的FDG的明胶块模拟中度压缩的乳房。用填充有代表恶性乳腺肿瘤中摄取量的FDG的四个中空球体（内径= 5mm、8mm、12mm和15mm）模拟病变（靶与背景浓度比= 8.5：1）。成像仪中心的分辨率为3.9 mm，灵敏度为0.059 kcps/kBq/ml，康普顿散射分数约为12%。在数据采集30 s后可以检测到直径小至8 mm的物体;在300 s后可以检测到5 mm的球体。随着乳房厚度的增加，目标检测能力降低。在薄压缩乳房（2厘米），即使是最小的球（直径5 mm）;乳腺厚度的增加使最小可检测球体直径增加到8 mm。与"脂肪"乳腺相比，乳房被模拟，并显示出对于乳房切除术，将最小可检测的损伤尺寸减小到12 mm。这些结果证明了PEM检测乳腺病变的潜力。将该系统添加到标准活检装置表明其用于引导乳腺癌的一些核心活检的潜力。
Positron emission mammography (PEM) is a new, specialized imaging modality utilizing PET radiopharmaceuticals to detect breast cancer. The capabilities and limitations of PEM in detecting breast tumors were investigated with a series of phantom experiments. The PEM imager was mounted on a standard Lorad biopsy table (separated by 18 cm). In the initial phase of the investigation, basic scanner parameters (resolution, sensitivity, and scatter fraction) were measured. The effects of a number of breast imaging parameters (length of acquisition, breast thickness, and breast density) on detection of breast lesions were then explored utilizing special phantoms. Moderately compressed breasts were simulated with a block of gelatin containing amounts of FDG consistent with 370 MBq injections. Lesions were simulated with four hollow spheres (inner diameters=5 mm, 8 mm, 12 mm, and 15 mm) filled with amounts of FDG representative of uptake in malignant breast tumors (target-to-background concentration ratio=8.5:1). Resolution at the center of the imager was 3.9 mm, sensitivity was 0.059 kcps/kBq/ml and the Compton scatter fraction was approximately 12%. Objects as small as 8 mm in diameter could be detected after 30 s of data acquisition; 5 mm spheres were detectable after 300 s. Object detection capabilities were reduced with increasing breast thickness. In thin compressed breasts (2 cm) even the smallest sphere (5 mm in diameter) could be detected; increasing breast thickness increased the minimum detectable sphere diameter to 8 mm. Increased background activity caused by FDG uptake in metabolically active normal tissue more prevalent in radiodense breasts compared to "fatty" breasts was simulated and shown to reduce the minimum detectable lesion size to 12 mm for the densest breasts. These results demonstrate the potential of PEM for the detection of breast lesions. The addition of the system to a standard biopsy apparatus indicates its potential for use to guide some core biopsies of breast cancers.