DIRECT TRANSLATION OF A CIRCULAR MESSENGER DNA

DIRECT TRANSLATION OF A CIRCULAR MESSENGER DNA
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DOI:
10.1038/2201088a0
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发表时间:
1968-01-01
期刊:
影响因子:
64.8
通讯作者:
BRETSCHER, MS
BRETSCHER, MS
中科院分区:
综合性期刊1区
文献类型:
--
作者:
BRETSCHER, MS

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甲酰甲硫基trna通过噬菌体fd的单链环状DNA与核糖体结合。将新霉素b加入到这个复合体中,允许将DNA直接翻译成蛋白质,这意味着核糖体不需要信使的自由端来启动蛋白质合成。
Formyl-methionyl-tRNA is bound to ribosomes by single stranded circular DNA of the phage fd. Addition of neomycinBto this complex permits direct translation of this DNA into protein, which implies that ribosomes do not require a free end on the messenger to initiate protein synthesis.