Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.
复制标题
饮食中的类黄酮 ( )-儿茶素和橙皮苷可抑制结肠异常隐窝的形成。
DOI：
10.1007/978-1-4757-5235-9_11
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发表时间：
2002
影响因子：
--
通讯作者：
Dashwood,RoderickH
中科院分区：
文献类型：
--
作者：
Franke,AdrianA;Custer,LaurieJ;Cooney,RobertV;Tanaka,Yuichiro;Xu,Meirong;Dashwood,RoderickH
大量流行病学研究证明，饮食预防被认为是减少癌症发病率和复发的最有希望的方法（Hill，1995）。大量细胞、动物和人类研究表明，类黄酮可以抑制癌症和心脏病（Middleton 和 Kandaswami，1994b；Das，1990；Weisburger，1992；Huang 和 Ferraro，1992；Wattenberg，1982；Hertog 等，1995）。尽管据报道对健康有益（Middleton 和 Kandaswami，1994a），但黄酮类的两个亚类，即在柑橘类水果中大量存在的黄烷酮（Mouly 等人，1993）和在核果、绿茶和红茶中大量存在的（+）-儿茶素（Graham，1992），最近开始研究它们的抗癌作用（Cody 等人，1992 年）。 1988）。大多数先前进行的研究仅考虑癌发生的晚期阶段，例如肿瘤生长或侵袭现象（Bracke 等人，1991；Kandaswami 等人，1991），而对茶化合物的研究则考虑粗茶提取物或没食子儿茶素（Mukhtar 等人，1992；Stich，1992）。类黄酮橙皮苷或黄烷酮(+)-儿茶素在癌发生的早期阶段预防癌症的作用以及这些药物的有效性，特别是在细胞水平上的有效性，很少有研究。
Dietary prevention is believed to be the most promising means by which incidence and recurrence of cancer can be reduced as evidenced by numerous epidemiologic studies (Hill, 1995). Flavonoids are known to inhibit cancer and heart disease as suggested by numerous cell, animal and human studies (Middleton and Kandaswami, 1994b; Das, 1990; Weisburger, 1992; Huang and Ferraro, 1992; Wattenberg, 1982; Hertog et al., 1995). Although reported to have beneficial health effects (Middleton and Kandaswami, 1994a) two subclasses of flavonoids, namely flavanones occurring abundantly in citrus fruits (Mouly et al., 1993) and (+)-catechins occurring in large amounts in pit fruits and green and black tea (Graham, 1992), emerge to be studied recently regarding their anti cancer effects (Cody et al., 1988). Most previously performed studies considered exclusively late stages of carcinogenesis such as tumor growth or invasion phenomena (Bracke et al., 1991; Kandaswami et al., 1991) and research on tea compounds considered either crude tea extracts or gallo-catechins (Mukhtar et al., 1992; Stich, 1992). Prevention of cancer by the flavonoid hesperidin or by the flavanone (+)-catechin at early stages of carcinogenesis and availability of these agents particularly on the cellular level are little investigated.