A granuloma annulare-like eruption associated with the use of amlodipine.
A granuloma annulare-like eruption associated with the use of amlodipine.
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DOI：
10.1046/j.1440-0960.2002.00547.x
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Murrell, Dedee
中科院分区：
文献类型：
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作者：
Lim, Adrian C;Hart, Kim;Murrell, Dedee
环状肉芽肿样药物反应是一种罕见的临床实体。，一名高加索女性，在服用氨氯地平13天后出现环状肉芽肿样反应，停药后3个月内痊愈。皮疹由多个红斑性瘙痒丘疹组成，对称地分布在小腿和大腿外侧，以及两个手掌上。组织学显示局灶性胶原变性和明显的间质组织细胞真皮浸润，提示为环状肉芽肿。我们回顾了以前报道的环状肉芽肿样药物反应的病例，结合最近提出的药物诱导的间质肉芽肿反应分类。
A granuloma annulare-like drug reaction is a rarely encountered clinical entity. A 64-year-old Caucasian female developed a granuloma annulare-like reaction 13 days after starting amlodipine and cleared within 3 months after drug cessation. The eruption consisted of multiple erythematous pruritic papules, distributed symmetrically over the lateral aspects of the legs and thighs, as well as on both palms. Histology showed focal collagen degeneration and significant interstitial histiocytic dermal infiltrate suggestive of granuloma annulare. We review previously reported cases of granuloma annulare-like drug reactions, in the context of a recently proposed classification for drug-induced interstitial granulomatous reactions.