Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents' marijuana problem severity at follow-up: A preliminary study
Regional brain activation supporting cognitive control in the context of reward is associated with treated adolescents' marijuana problem severity at follow-up: A preliminary study
复制标题
DOI：
10.1016/j.dcn.2015.05.004
复制
发表时间：
2015-12-01
影响因子：
4.7
通讯作者：
Clark, Duncan B.
中科院分区：
文献类型：
--
作者：
Chung, Tammy;Paulsen, David J.;Clark, Duncan B.
这项初步研究考察了青少年药物使用者6个月治疗结果与奖赏提示反扫视（AS）任务期间脑区域激活的关联程度。反扫视性能提供了执行功能和认知控制的敏感测量，并且通常在奖励提示下得到改善。我们假设，当准备执行AS时，支持AS的认知和动眼控制相关区域的更大激活，特别是在奖励提示试验期间，将与6个月随访时较低的物质使用严重程度相关。从社区门诊治疗中招募的青少年（n = 14，年龄14-18岁）完成了fMRI奖励提示AS任务（奖励和中性条件），并提供了随访数据。结果表明，与中性试验相比，AS错误在奖励方面有所减少。然而，AS行为表现与治疗结果无关。正如假设的那样，在奖励试验中，与认知（如腹外侧前额叶皮层）和眼球运动控制（如辅助视野）相关的兴趣区域（roi）的激活与6个月时大麻问题的严重程度呈负相关。中性试验期间的ROI激活与结果无关。结果支持动机（奖励线索）因素在增强认知控制过程中的作用，并提示青少年治疗结果可能存在基于大脑的关联。(C) 2015年作者。Elsevier Ltd.出版。
This preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS) task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and generally improves with reward cues. We hypothesized that when preparing to execute an AS, greater activation in regions associated with cognitive and oculomotor control supporting AS, particularly during reward cue trials, would be associated with lower substance use severity at 6-month follow-up. Adolescents (n = 14, ages 14-18) recruited from community-based outpatient treatment completed an fMRI reward cue AS task (reward and neutral conditions), and provided follow-up data. Results indicated that AS errors decreased in reward, compared to neutral, trials. AS behavioral performance, however, was not associated with treatment outcome. As hypothesized, activation in regions of interest (ROIs) associated with cognitive (e.g., ventrolateral prefrontal cortex) and oculomotor control (e.g., supplementary eye field) during reward trials were inversely correlated with marijuana problem severity at 6-months. ROI activation during neutral trials was not associated with outcomes. Results support the role of motivational (reward cue) factors to enhance cognitive control processes, and suggest a potential brain-based correlate of youth treatment outcome. (C) 2015 The Authors. Published by Elsevier Ltd.