Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma
Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma
复制标题
DOI：
10.1002/pros.20311
复制
发表时间：
2006-04-01
期刊：
影响因子：
2.8
通讯作者：
Iversen, P
中科院分区：
文献类型：
--
作者：
Brasso, K;Christensen, IJ;Iversen, P
背景探讨骨代谢标志物（血清PINP、BAP和CTX-I）和血清YKL-40在转移性前列腺癌（PC）中的预后价值。在153例转移性PC患者接受胃肠外雌激素或雄激素消融治疗前，通过ELISA测定生物标志物。中位随访时间为4.9年。115名患者死亡。与对照组相比，患者的生物标志物增加（P < 0.001），并且与体力状态和Soloway评分（YKL-40除外）相关，但与T分类和WHO肿瘤分级无关。PINP升高87%，BAP升高55%，CTX-1升高33%，YKL-40升高43%。单变量分析显示与生存相关：PINP（HR = 1.6，P < 0.0001）、BAP（HR = 1.4，P < 0.0001）、CTX-1（HR = 1.7，P < 0.0001）和YKL-40（HR = 1.4，P = 0.004）。多因素考克斯分析中，体力状态、WHO分级、Soloway评分、PINP和YKL-40是独立的预测因素。高血清PINP、BAP、CTX-I和YKL-40与转移性PC患者的不良结局相关。前列腺66：503-513，2006年。(c)2005 Wiley-Liss，Inc.
BACKGROUND. To examine the prognostic value of markers of bone metabolism (serum PINP, BAP, and CTX-I) and serum YKL-40 in metastatic prostate carcinoma (PC).METHODS. The biomarkers were determined by ELISAs in 153 metastatic PC patients before treatment with parenteral estrogen or total androgen ablation. The median follow-up was 4.9 years. One hundred fifteen patients died.RESULTS. The biomarkers were increased in the patients compared to controls (P < 0.001), and related to performance status and Soloway score (except YKL-40), but not to T-category and WHO tumor grade. PINP was elevated in 87%, BAP (55%), CTX-I (33%), and YKL-40 (43%). Univariate analysis showed an association to survival: PINP (HR = 1.6, P < 0.0001), BAP (HR = 1.4, P < 0.0001), CTX-I (HR = 1.7, P < 0.0001), and YKL-40 (HR = 1.4, P = 0.004). In multivariate Cox analysis performance status, WHO grade, Soloway score, PINP, and YKL-40 were independently predictive factors.CONCLUSIONS. High serum PINP, BAP, CTX-I, and YKL-40 are associated with poor outcome of metastatic PC patients. Prostate 66: 503-513, 2006. (c) 2005 Wiley-Liss, Inc.