Safety of rapid-rate transcranial magnetic stimulation: Heart rate and blood pressure changes
Safety of rapid-rate transcranial magnetic stimulation: Heart rate and blood pressure changes
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DOI：
10.1016/s0168-5597(97)00016-6
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发表时间：
1997-05-01
期刊：
影响因子：
--
通讯作者：
Claus, D
中科院分区：
文献类型：
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作者：
Foerster, A;Schmitz, JM;Claus, D
我们研究了快速经颅磁刺激对 13 名健康志愿者的心率和血压的影响。在第一个系列中，应用了三种不同的皮质磁刺激：在 C3、C4 和 Fz（10/20 系统）上，在第二个系列中另外在 Pz 上。我们还使用了臂丛神经刺激和假刺激。使用使用焦点圆形线圈的 Cadwell 高速磁刺激器对每个位置施加五次刺激。刺激序列持续时间为 500 毫秒，刺激频率为 20 Hz。刺激强度为最大刺激器输出的 70-90%，最大刺激器输出的 20% 高于受试者的个体运动阈值。受试者在刺激后立即评估刺激的不便。在 1 小时测试期间连续记录心电图和血压 (Finapres)。在所有刺激后，所有受试者都出现明显的自主反应，心率加快，血压下降。皮质刺激之间的反应没有差异。假刺激后血压下降明显小于皮质刺激后，臂丛神经刺激后血压下降更明显。自主反应与对刺激不便的主观估计密切相关。我们得出的结论是，观察到的快速经颅磁刺激的效果与非特异性唤醒反应有关，而不是与自主皮质区域的直接刺激有关。我们没有观察到任何临床相关的副作用。 (C) 1997 爱思唯尔科学爱尔兰有限公司
We examined the influence of rapid-rate transcranial magnetic stimulation on heart rate and blood pressure in 13 healthy volunteers. In a first series three different cortical magnetic stimuli were applied: over C3, C4 and Fz (10/20 system), in a second series additionally over Pz. We also used a stimulus over the brachial plexus and a sham stimulus. Five stimuli of each location were applied with a Cadwell high speed magnetic stimulator using a focal point circular coil. Stimulus train duration was 500 ms, stimulus frequency 20 Hz. Stimulus strength was 70-90% of maximum stimulator output, 20% of maximum stimulator output above subjects' individual motor threshold. The subjects assessed stimulus inconvenience immediately after stimulation. ECG and blood pressure (Finapres) were recorded continuously during the 1 h test. In all subjects there was a clearly marked autonomic response with heart rate acceleration and decrease in blood pressure after all stimuli. There was no difference in responses between cortical stimuli. Blood pressure decrease after sham stimulation was significantly smaller than after cortical stimulation, it was more marked after brachial plexus stimulation. Autonomic reaction correlates well with subjective estimation of stimulus inconvenience. We conclude the observed effect of rapid-rate transcranial magnetic stimulation to be associated to rather an unspecific arousal reaction than to a direct stimulation of autonomic cortex areas. We did not observe any clinically relevant side-effects. (C) 1997 Elsevier Science Ireland Ltd.