TGF-β1 is essential for the homeostasis of the dentin-pulp complex
TGF-β1 is essential for the homeostasis of the dentin-pulp complex
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DOI：
10.1111/j.1600-0722.1998.tb02174.x
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发表时间：
1998-01-01
影响因子：
1.9
通讯作者：
Letterio, J
中科院分区：
文献类型：
--
作者：
D'Souza, RN;Cavender, A;Letterio, J
在发育和修复过程中影响成牙本质细胞功能的复杂细胞因子网络中。 TGF-β1 的独特之处在于其双重能力，既可作为有效的免疫抑制剂，又可作为细胞外基质生成的诱导剂。这些特性强调了该分子在损伤后维持牙本质-牙髓复合物稳态的重要性。本文的目的是描述我们对 TGF-β 1 基因被破坏的小鼠牙列进行表型分析的新发现。 TGF-β1(-/-)后代的主要表型是弥漫性免疫系统激活伴进行性炎症；浪费和死亡。我们的研究显示成人 TGF-β 1(-/-) 牙列存在广泛的牙髓和根尖周炎症和坏死。此外，咬合磨牙的冠面显示出明显的磨损。为了确定 TGF-β 1(-/-) 牙列的表型变化是否与 TGF-β 1 的缺失而不是炎症过程本身直接相关，我们研究了与免疫缺陷背景回交的 TGF-β 1(-/-) 小鼠的成年牙列。我们的组织病理学和放射学分析结果表明，TGF-β 1(-/-) 免疫缺陷小鼠的牙齿在牙髓和根尖区域保持活力，但咬合面显示过度磨损。
Among the complex network of cytokines that influence odontoblast function during development and repair. TGF-beta 1 is unique in its dual abilities to function as a potent immunosuppressant and as an inducer of extracellular matrix production. These properties underscore the importance of this molecule in maintaining the homeostasis of the dentin-pulp complex after injury. The purpose of this paper is to describe new findings of our phenotypic analysis of dentition in mice in which the TGF-beta 1 gene has been disrupted. The major phenotype of TGF-beta 1(-/-) offspring is one of diffuse immune system activation with progressive inflammation; wasting and death. Our studies elf adult TGF-beta 1(-/-) dentition show widespread pulpal and periapical inflammation and necroses. In addition, the coronal surfaces of occluding molars show marked attrition. To determine whether the phenotypic changes in TGF-beta 1(-/-) dentition are directly linked to the loss of TGF-beta 1 rather than the inflammatory process itself, we studied adult dentition in TGF-beta 1(-/-) mice backcrossed into immunodeficient backgrounds. Results of our histopathologic and radiographic analyses show that teeth of TGF-beta 1(-/-) immunodeficient mice retain vitality in pulpal and periapical regions but show excessive wear of occlusal surfaces.