Understanding Dementia Prevalence Among Centenarians
Understanding Dementia Prevalence Among Centenarians
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DOI：
10.1093/gerona/glr250
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发表时间：
2012-04-01
影响因子：
5.1
通讯作者：
Markesbery, William
中科院分区：
文献类型：
--
作者：
Poon, Leonard W.;Woodard, John L.;Markesbery, William
本文的目标是：(a)建立全球退化量表在评估百岁老人认知功能和痴呆阶段中的并发性和临床有效性，(b)确定百岁老人代表性样本中全因痴呆的患病率，以及(c)证明样本人口统计学特征的变化如何显著影响痴呆患病率的估计。在244名百岁老人中，有四分之一的人没有记忆缺陷的客观证据。另有四分之一的人表现出短暂的神志不清的迹象，大约一半的人表现出痴呆的典型行为迹象，在全球恶化量表的第4-6阶段各约占15%，在最严重的第7阶段约占5%。研究发现，年龄、性别、种族、居住状态和受教育程度的差异以及用于痴呆评级的标准都会影响患病率。
The goals of this article are to (a) establish the concurrent and clinical validity of the Global Deterioration scale in assessing cognitive functions and stages of dementia among centenarians, (b) identify the prevalence of all-cause dementia in representative samples of centenarians, and (c) demonstrate how variations in sample demographic characteristics could significantly affect estimates of dementia prevalence. A quarter of the 244 centenarians in a population-based sample had no objective evidence of memory deficits. Another quarter showed signs of transient confusion, and about half showed classical behavioral signs of dementia with about 15% in each of Global Deterioration scale stages 4-6 and about 5% in the most severe stage 7. Variations in age, gender, race, residence status, and education of the study sample as well as criteria used for dementia rating were found to affect prevalence.