Sex-Based Differences in Asthma among Preschool and School-Aged Children in Korea.
Sex-Based Differences in Asthma among Preschool and School-Aged Children in Korea.
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DOI：
10.1371/journal.pone.0140057
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Shin A
中科院分区：
文献类型：
--
作者：
Jang Y;Shin A
本研究的目的是利用2009-2011年韩国国家健康与营养检查调查（KNHANES）的代表性国家数据集，探讨学龄前和学龄儿童哮喘患病率的相关危险因素。我们评估了3,542名4-12岁儿童的人口统计信息、健康状况、家庭环境、社会经济状况和父母健康状况。在考虑了主要样本单位、分层和样本权重后，采用性别分层多因素logistic回归获得校正患病率优势比（ORs）和95%置信区间。4 ~ 12岁儿童哮喘患病率中，男孩为7.39%，女孩为6.27%。患有特应性皮炎的男孩和女孩比没有特应性皮炎的男孩更容易患哮喘（男孩：OR = 2.20, p = 0.0071；女孩：OR = 2.33, p = 0.0031）。父母≥1人哮喘的男孩和女孩患哮喘的可能性高于父母无哮喘的男孩和女孩（男孩：OR = 3.90, p = 0.0006；女孩：OR = 3.65, p = 0.0138）。随着女孩年龄的增长，哮喘患病率降低（OR = 0.90, p = 0.0408）。居住在农村地区的女孩患哮喘的可能性比居住在城市地区的女孩低60% （p = 0.0309）。家庭成员≥5人的男孩患哮喘的可能性高于家庭成员≤3人的男孩（OR = 2.45, p = 0.0323）。学龄前和学龄儿童哮喘患病率的相关因素可能因性别而异。通过了解哮喘性别差异的特点，可以在临床上制定个体化的哮喘管理方案。
The purpose of this study was to explore risk factors related to asthma prevalence among preschool and school-aged children using a representative national dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2009–2011. We evaluated the demographic information, health status, household environment, socioeconomic status, and parents’ health status of 3,542 children aged 4–12 years. A sex-stratified multivariate logistic regression was used to obtain adjusted prevalence odds ratios (ORs) and 95% confidence intervals after accounting for primary sample units, stratification, and sample weights. The sex-specific asthma prevalence in the 4- to 12-year-old children was 7.39% in boys and 6.27% in girls. Boys and girls with comorbid atopic dermatitis were more likely to have asthma than those without atopic dermatitis (boys: OR = 2.20, p = 0.0071; girls: OR = 2.33, p = 0.0031). Boys and girls with ≥1 asthmatic parent were more likely to have asthma than those without asthmatic parents (boys: OR = 3.90, p = 0.0006; girls: OR = 3.65, p = 0.0138). As girls got older, the prevalence of asthma decreased (OR = 0.90, p = 0.0408). Girls residing in rural areas were 60% less likely to have asthma than those residing in urban areas (p = 0.0309). Boys with ≥5 family members were more likely to have asthma than those with ≤3 family members (OR = 2.45, p = 0.0323). The factors related to asthma prevalence may differ depending on sex in preschool and school-aged children. By understanding the characteristics of sex-based differences in asthma, individualized asthma management plans may be established clinically.