Prevalence of astigmatism in infant monkeys
Prevalence of astigmatism in infant monkeys
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DOI：
10.1016/s0042-6989(02)00060-3
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发表时间：
2002-05-01
期刊：
影响因子：
1.8
通讯作者：
Smith, EL
中科院分区：
文献类型：
--
作者：
Kee, CS;Hung, LF;Smith, EL
目的：人类婴儿散光的患病率很高。尽管猕猴通常被用作早期眼睛生长和正视化实验的动物模型，但幼猴散光的患病率尚未被探索。在这项研究中，我们检查了幼猴散光的患病率和性质。方法：分别使用散瞳验光和角膜曲率测量方法测量 132 只 2-5 周龄恒河猴 (Macaca mulatta) 的屈光和角膜散光。对 16 名正常婴儿在出生后前 6 个月内的屈光发育进行纵向测量。结果：小猴的散光患病率较低。大约 90% 的 2-5 周大婴儿的屈光或角膜散光< 1.00 D。观察屈光散光时，它与角膜散光的方向和大小有很好的相关性。当角膜散光 > 1.00 D (n = 20) 时，本质上主要是违规 (70.0%)。纵向追踪的幼猴在观察期间的任何时间都很少表现出明显的散光误差。当这些幼猴表现出明显的散光时，通常是短暂的，并且在随后的测量中不会出现。结论：与人类婴儿不同，幼猴表现出相对较少的散光。早期发育过程中散光的患病率较低，这表明散光并不能为婴儿灵长类动物依赖视力的眼睛生长提供必要的线索。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Purpose: Human infants exhibit a high prevalence of astigmatism. Although macaque monkeys are commonly used as animal models in experiments on early ocular growth and emmetropization, the prevalence of astigmatism in infant monkeys is unexplored. In this study we examine the prevalence and nature of astigmatism in infant monkeys.Methods: Refractive and corneal astigmatism were measured in 132, 2-5-week-old rhesus monkeys (Macaca mulatta) using cycloplegic retinoscopy and keratometry, respectively. Longitudinal measures of refractive development were obtained from 16 normal infants over the first 6 months of life.Results: Infant monkeys exhibited a low prevalence of astigmatism. Approximately 90%,, of the 2-5-week-old infants had < 1.00 D of either refractive or corneal astigmatism. When refractive astigmatism was observed, it was well correlated with the direction and magnitude of corneal astigmatism. When corneal astigmatism was > 1.00 D (n = 20), it was predominantly against-the-rule in nature (70.0%). The infant monkeys that were followed longitudinally rarely showed significant astigmatic errors at any time during the observation period. When these infant monkeys exhibited significant astigmatism, it was usually transient and not present on subsequent measurements.Conclusions: Unlike human infants, infant monkeys exhibit relatively little astigmatism. The low prevalence of astigmatism during early development suggests that astigmatism does not provide an essential cue for vision-dependent eye growth in infant primates. (C) 2002 Elsevier Science Ltd. All rights reserved.