Plus disease in retinopathy of prematurity: quantitative analysis of vascular change.
Plus disease in retinopathy of prematurity: quantitative analysis of vascular change.
复制标题
早产儿视网膜病变的附加疾病：血管变化的定量分析。
DOI：
10.1016/j.ajo.2010.04.027
复制
发表时间：
2010
影响因子：
4.2
通讯作者：
Chiang,MichaelF
中科院分区：
文献类型：
--
作者：
Thyparampil,PreetiJ;Park,Yangseon;Martinez-Perez,ME;Lee,ThomasC;Weissgold,DavidJ;Berrocal,AudinaM;Chan,RVPaul;Flynn,JohnT;Chiang,MichaelF
回顾性观察病例对照研究方法对37例经后31 ~ 33周和35 ~ 37周的婴儿进行双侧广角X线摄影。使用半自动视网膜图像多尺度分析系统测量所有动脉和静脉的参数：综合曲率、直径和迂曲指数。在35 - 37周PMA时，由5名专家达成共识，确定每只眼睛的参考标准诊断（+vs非+）。比较正眼与非正眼的每周参数变化率。根据1）PMA第31至33周和第35至37周之间的每周参数变化率和2）仅在第35至37周的参数值，计算阳性疾病检测的受试者工作特征曲线下面积（AUC）。特别是弯曲指数（P <0.0004）和直径（P = 0.018）。使用每周变化率，静脉迂曲指数（0.819）和静脉直径（0.712）的阳性疾病检测AUC最高。仅使用35 - 37周PMA图像，静脉综合曲率（0.952）和直径（0.789）的AUC最高。结论：在该数据集中，静脉参数而非动脉参数的变化率与疾病发展相关。除了35 - 37周PMA时的图像分析外，这似乎没有提供其他信息。
PURPOSETo examine the relationship between rate of vascular change and plus disease diagnosis.DESIGNRetrospective observational case-control study.METHODSWide-angle images were taken bilaterally from 37 infants at 31 to 33 weeks and 35 to 37 weeks postmenstrual age (PMA). The semi-automated Retinal Image multiScale Analysis system was used to measure parameters for all arteries and veins: integrated curvature, diameter, and tortuosity index. A reference standard diagnosis (plus vs not plus) was defined for each eye by consensus of 5 experts at 35 to 37 weeks PMA. Weekly rate of change in parameters was compared in eyes with plus vs not plus disease. Receiver operating characteristic area under the curve (AUC) was calculated for plus disease detection based on 1) weekly rates of parameter change between 31 to 33 weeks and 35 to 37 weeks PMA and 2) parameter values at 35 to 37 weeks only.RESULTSWeekly rates of change in all venous parameters were significantly different in eyes with plus vs not plus disease, particularly for tortuosity index (P < .0004) and diameter (P = .018). Using weekly rate of change, AUC for plus disease detection was highest for venous tortuosity index (0.819) and venous diameter (0.712). Using the 35 to 37-week PMA image only, AUC was highest for venous integrated curvature (0.952) and diameter (0.789).CONCLUSIONRate of change in venous, but not arterial, parameters is correlated with plus disease development in this data set. This did not appear to contribute information beyond analysis of an image at 35 to 37 weeks PMA only.