Mapping quantitative trait loci for milk production traits on ovine chromosome 6
Mapping quantitative trait loci for milk production traits on ovine chromosome 6
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DOI：
10.1017/s0022029901004988
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发表时间：
2001-08-01
影响因子：
2.1
通讯作者：
San Primitivo, F
中科院分区：
文献类型：
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作者：
Diez-Tascón, C;Bayón, Y;San Primitivo, F
采用子代设计研究了西班牙Churra羊6号染色体上影响产奶性状的数量性状基因座（QTL）。8个半同胞家庭的基因型为11个微卫星和标记QTL的影响进行了分析，产量偏差（YD）作为定量测量以下性状：牛奶产量，蛋白质产量和蛋白质百分比。QTL分析采用基于多标记回归原理的区间作图法。通过排列检验估计显著性阈值，然后进行多重检验校正。结果表明，绵羊6号染色体上的一个区域，接近酪蛋白簇，对牛奶性状，特别是对蛋白质百分比的影响。这些结果，第一个报告的QTL影响牛奶性状的羊，讨论了有关的数据，牛，密切相关的物种。
Spanish Churra sheep were studied in a daughter design for the presence on chromosome 6 of quantitative trait loci (QTL) influencing milk production traits. Eight half-sib families were genotyped for 11 microsatellites and marker-QTL effects analysed using yield deviations (YD) as quantitative measurements for the following traits: milk yield, protein yield, and protein percentage. QTL analysis was performed by interval mapping based on multimarker regression principles. Significance thresholds were estimated through a permutation test followed by a correction for multiple testing. The results suggest a region on ovine chromosome 6, close to the casein cluster, with an influence on milk traits and particularly on protein percentage. These results, the first ones reported for QTL affecting milk traits in sheep, are discussed in relation to data available for cattle, a closely related species.