Response inhibition is associated with white matter microstructure in children
Response inhibition is associated with white matter microstructure in children
复制标题
DOI：
10.1016/j.neuropsychologia.2009.11.001
复制
发表时间：
2010-03-01
期刊：
影响因子：
2.6
通讯作者：
Jernigan, Terry L.
中科院分区：
文献类型：
--
作者：
Madsen, Kathrine Skak;Baare, William F. C.;Jernigan, Terry L.
对思想、行动和情绪的认知控制对于正常行为很重要，这种控制的发展在整个童年和青春期持续进行。多项证据表明，反应抑制主要由涉及额下回 (IFG)、前辅助运动皮层 (preSMA) 和丘脑底核的右侧网络介导。尽管已知大脑的纤维束在儿童时期发育，但人们对于该网络内的纤维束发育如何与发展行为控制相关的了解却很少。在这里，我们研究了典型发育儿童的反应抑制（通过停止信号任务测量）与区域白质微结构指数之间的关系。我们假设在控制年龄后，更好的反应抑制性能与右侧 IFG 和 preSMA 内纤维束中较高的各向异性分数 (FA) 相关。从左右 IFG 和 preSMA 中提取平均 FA 和扩散率值。正如假设的那样，更快的反应抑制与右侧 IFG 和右侧 preSMA 中较高的 FA 和较低的垂直扩散率显着相关，这可能反映了更密集或更好的有髓纤维束内神经传导的更快速度。此外，在控制这些 DTI 参数的年龄和全脑估计后，这两种影响仍然显着。有趣的是，正确的 IFG 和 preSMA FA 对性能变异性的预测做出了额外贡献。观察到的关联可能与成熟阶段的变化、支持反应抑制的网络中的活动依赖性改变有关，或者与潜在神经系统连接性的稳定个体差异有关。 (C) 2009 Elsevier Ltd. 保留所有权利。
Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity. (C) 2009 Elsevier Ltd. All rights reserved.