Alteration of occlusal vertical dimension induces signs of neuroplastic changes in corticomotor control of masseter muscles: Preliminary findings
Alteration of occlusal vertical dimension induces signs of neuroplastic changes in corticomotor control of masseter muscles: Preliminary findings
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DOI：
10.1111/joor.12682
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发表时间：
2018-09-01
影响因子：
2.9
通讯作者：
Svensson, Peter
中科院分区：
文献类型：
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作者：
Deng, Hongyan;Gao, Shang;Svensson, Peter
目的通过导航经颅磁刺激（nTMS）观察重度磨耗患者改变咬合垂直尺寸（OVD）对咬肌皮质运动控制的影响。方法对7例（58.68.4岁）因严重磨损导致OVD下降的患者采用下颌咬合夹板改变OVD，并指导患者在清醒时间内佩戴，持续4周。在基线和OVD改变后至少4周，用nTMS记录咬肌和第一背骨间肌的运动诱发电位（MEPs）和运动皮质图。采用双向重复测量方差分析分析mep的刺激-反应曲线，采用配对t检验分析数值评定量表得分、运动阈值、发作潜伏期、运动皮质图和重心（COG）。结果OVD改变4周后，大鼠咬肌MEPs振幅显著增加（P=0.036），运动皮质图区无明显变化（P=0.111）。此外，OVD改变前后FDI肌mep振幅（P=0.466）和运动皮质图面积（P=0.230）均无显著差异。结论严重磨损患者的OVD改变与咬肌皮质运动控制的神经可塑性改变有关。这项研究的结果可能会增加我们对OVD改变时皮层变化相关的假定机制的理解。
PurposeTo investigate the effect of altering occlusal vertical dimension (OVD) in patients with severe attrition on corticomotor control of the masseter muscles as assessed by navigated transcranial magnetic stimulation (nTMS).MethodsSeven patients (58.68.4years) with decreased OVD due to severe attrition were given mandibular occlusal splints to alter the OVD with the instruction to wear during the whole awake time for a period of four weeks. Motor-evoked potentials (MEPs) and the motor cortex maps of the masseter muscles and first dorsal interosseous (FDI) muscles as control were recorded by nTMS at baseline and at least 4weeks after the alteration of OVD. The stimulus-response curves of MEPs were analysed with two-way repeated-measures ANOVA, and the numerical rating scale scores, motor thresholds, onset latencies, motor cortex maps and centre of gravity (COG) were analysed with paired t tests.ResultsThere was a significant increase in the amplitude of the masseter muscle MEPs (P=0.036), but no change in the motor cortex map areas (P=0.111) four weeks after the alteration of OVD. Furthermore, there was no significant difference in either the amplitude of the FDI muscle MEPs (P=0.466) or the motor cortex map areas (P=0.230) before and after OVD alteration.ConclusionThe results suggest that alteration of OVD in patients with severe attrition was associated with signs of neuroplastic changes in the corticomotor control of the masseter muscles. The results of the study may add to our understanding of the putative mechanisms related to cortical changes in response to OVD alterations.