Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
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DOI：
10.1016/s0896-6273(01)00447-0
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发表时间：
2001-10-11
期刊：
影响因子：
16.2
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Harris, KD;Hirase, H;Buzsáki, G
皮质锥体细胞发射单个尖峰和复杂尖峰爆发。然而，触发复杂尖峰所需的条件及其计算功能都不清楚，在行为大鼠中检查了 CA1 锥体细胞爆发活动。爆发的比例并不是在场中心的地方更高，而是在放电频率为 6-7 Hz 的地方更高。与长时间静默（100 ms-1 s）后相比，近期尖峰活动后的突发概率较低且突发时间较短。爆发起始概率和爆发长度与细胞外尖峰幅度和细胞内动作电位上升斜率相关。我们认为突发可能起到“条件同步检测器”的作用，在神经元沉默后发出强烈的传入同步信号，并且由弱输入触发的单个尖峰可能会抑制随后的强输入引起的突发。
Cortical pyramidal cells fire single spikes and complex spike bursts, However, neither the conditions necessary for triggering complex spikes, nor their computational function are well understood, CA1 pyramidal cell burst activity was examined in behaving rats. The fraction of bursts was not reliably higher in place field centers, but rather in places where discharge frequency was 6-7 Hz. Burst probability was lower and bursts were shorter after recent spiking activity than after prolonged periods of silence (100 ms-1 s). Burst initiation probability and burst length were correlated with extracellular spike amplitude and with intracellular action potential rising slope. We suggest that bursts may function as "conditional synchrony detectors," signaling strong afferent synchrony after neuronal silence, and that single spikes triggered by a weak input may suppress bursts evoked by a subsequent strong input.