IMMUNOLOGIC UNRESPONSIVENESS INDUCED BY PROTEIN ANTIGENS
IMMUNOLOGIC UNRESPONSIVENESS INDUCED BY PROTEIN ANTIGENS
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DOI：
10.1084/jem.101.3.245
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发表时间：
1955-01-01
影响因子：
15.3
通讯作者：
MAURER, PH
中科院分区：
文献类型：
--
作者：
DIXON, FJ;MAURER, PH
反复大量输注异源血浆蛋白可诱导家兔出现特异性免疫无反应状态。在大多数正常成年兔中，这种无反应性仅持续约与宿主中可检测到异源蛋白的时间一样长（3-4个月）。从出生时开始输注的兔子，也许是X射线照射的成年兔子，诱导的免疫无反应性持续整个观察期（10-11个月），在所有可检测到的外源蛋白消失后很久。这种无反应性似乎对过量施用的抗原具有特异性，并且不会阻止对甚至密切相关的抗原的抗体反应。无反应性没有传递给第一代后代。在正常成年兔中发生的暂时无反应性的机制可能取决于宿主中抗原的实际存在。然而，这种无反应性并不像肺炎球菌多糖诱导的免疫麻痹那样，是由抗原形成的抗体的简单中和引起的。另一方面，在“新生儿”和可能的X射线照射的兔子中形成的持久免疫无反应性的机制可能取决于宿主对外来蛋白的接受，因为它基本上是非抗原性的。在异卵双胞胎之间自然发生的不同红细胞类型的胎盘转移中也可以看到类似的情况。
Repeated large infusions of heterologous plasma proteins can induce a state of specific immunologic unresponsiveness in rabbits. In most normal adult rabbits this unresponsiveness lasts only about as long as the heterologous proteins are detectable in the host (3-4 months). In rabbits infused from the time of birth and perhaps X-radiated adult rabbits the induced immunologic unresponsiveness lasted throughout the period of observation (10-11 months), long after disappearance of all detectable foreign proteins. This unresponsiveness appears to be specific for the antigens administered in excess and does not prevent antibody responses to even closely related antigens. The unresponsiveness was not transmitted to 1st generation offspring. The mechanism of the temporary unresponsiveness which occurs in normal adult rabbits may be dependent upon the actual presence of the antigen in the host. However, the unresponsiveness does not result from a simple neutralization of antibody, as it is formed, by the antigen, as was suggested in the case of pneumococcal polysaccharide induced immunologic paralysis. On the other hand, the mechanism of the lasting immunologic unresponsiveness developing in the "newborn" and perhaps the X-rayed rabbits may depend upon the acceptance of the foreign protein as essentially non antigenic by the host. A similar situation is seen in the naturally occurring placental transfer of dissimilar red blood cell types between fraternal twins.