Clinical Risk Factors for Thoracic Ossification of the Ligamentum Flavum: A Cross-Sectional Study Based on Spinal Thoracic Three-Dimensional Computerized Tomography.
Clinical Risk Factors for Thoracic Ossification of the Ligamentum Flavum: A Cross-Sectional Study Based on Spinal Thoracic Three-Dimensional Computerized Tomography.
复制标题
胸椎黄韧带骨化的临床危险因素：基于脊柱胸椎三维计算机断层扫描的横断面研究
DOI：
10.2147/rmhp.s361730
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发表时间：
2022
影响因子：
3.5
通讯作者：
Wang, Chao
中科院分区：
文献类型：
--
作者：
Zhang, Hao;Deng, Nian;Zhang, Lu;Zhang, Lei;Wang, Chao
先前有限的研究报告了与胸椎黄韧带骨化（TOLF）相关的临床危险因素的结果不一致。本回顾性研究旨在通过回顾性横断面研究探讨TOLF的潜在危险因素，为进一步的临床和病理生理学研究提供宝贵的经验。根据筛选标准，共有2247名2016年1月至2019年12月在我机构接受脊柱胸廓三维计算机断层扫描（3D-CT）扫描的无症状参与者参加本研究。记录人口统计信息，如年龄、性别、身高、体重、体重指数（BMI）、吸烟和饮酒史、舒张压（DBP）、收缩压（SBP）和脉压（PP）。实验室结果包括血清低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、甘油三酯（TG）、尿酸（UA）、肌酐（Cr）、钙和磷。根据胸部3D-CT表现将受试者分为TOLF组和非TOLF组。在 153 名（6.81%）无症状参与者中观察到 TOLF。两组人口统计数据和实验室检查的比较显示，TOLF组的参与者年龄较大，BMI较高，舒张压水平较高。此外，两组间性别、饮酒、吸烟、SBP、TC、TG、PP以及LDL-C、HDL-C、sUA、sCr、钙、磷水平无显着差异。此外，二分逻辑回归分析显示年龄（OR = 1.018，p = 0.041）和BMI（OR = 1.090，p < 0.001）是TOLF的危险因素。我们的研究表明，年龄和BMI是TOLF发生的临床危险因素，而在亚组分析中，年龄不能被确定为女性的独立危险因素。
Inconsistent results of the clinical risk factors associated with thoracic ossification of the ligamentum flavum (TOLF) have been reported in limited previous studies. This retrospective study aimed to investigate the potential risk factors for TOLF by a retrospective cross-sectional study, which may provide valuable experience for further clinical and pathophysiological research. A total of 2247 asymptomatic participants, who underwent spinal thoracic three-dimensional computerized tomography (3D-CT) scans at our institution from January 2016 to December 2019, were enrolled in this study according to the screening criteria. Demographic information such as age, sex, height, weight, body mass index (BMI), smoking and drinking history, diastolic blood pressure (DBP), systolic blood pressure (SBP), and pulse pressure (PP) were recorded. Laboratory results included serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG), uric acid (UA), creatinine (Cr), calcium, and phosphorus. Participants were divided into TOLF group and non-TOLF group in accordance with the thoracic 3D-CT manifestation. TOLF was observed in 153 (6.81%) asymptomatic participants. Comparison of demographic data and laboratory examinations between the two groups showed that participants in the TOLF group were older, had a higher BMI, as well as higher levels of DBP. In addition, there was no significant difference in sex, drinking, tobacco use, SBP, TC, TG, PP, and levels of LDL-C, HDL-C, sUA, sCr, calcium, and phosphorus between the two groups. Furthermore, dichotomous logistic regression analyses revealed that age (OR = 1.018, p = 0.041) and BMI (OR = 1.090, p < 0.001) were risk factors for TOLF. Our study reveals that age and BMI are clinical risk factors for the development of TOLF, while age cannot be identified as an independent risk factor for female in subgroup analysis.