Mom's milk molds neural wiring for metabolism.
Mom's milk molds neural wiring for metabolism.
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母乳塑造新陈代谢的神经线路。
DOI：
10.1016/j.cell.2014.01.033
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发表时间：
2014
期刊：
影响因子：
64.5
通讯作者：
Ozcan,Umut
中科院分区：
文献类型：
--
作者：
Cakir,Isin;Ozcan,Umut
沃格特等人证明，在小鼠中，哺乳期的母体高脂肪喂养足以使后代在其一生中的能量和葡萄糖稳态受损。他们揭示了后代中产生的异常胰岛素信号干扰了下丘脑神经回路的形成，这些神经回路有助于代谢状态。
Vogt et al. demonstrate that, in mice, maternal high-fat feeding during lactation is sufficient to program the offspring for impaired energy and glucose homeostasis throughout their lifetime. They reveal that the resulting abnormal insulin signaling in the offspring interferes with the formation of hypothalamic neural circuits that contribute to metabolic status.