The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010.
The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010.
复制标题
肥胖对美国非怀孕成人和儿童血汞水平的影响：NHANES 2007-2010。
DOI：
10.1016/j.envres.2015.01.018
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发表时间：
2015
影响因子：
8.3
通讯作者：
Fayad,Raja
中科院分区：
文献类型：
--
作者：
Rothenberg,SarahE;Korrick,SusanA;Fayad,Raja
背景在动物研究中，肥胖与较高的血液和组织汞浓度有关。然而缺乏人类研究。虽然这种关联的机制尚不清楚，但肥胖可能会改变甲基汞的代谢和分布。目的在通过鱼类和贝类消费以及其他混杂因素控制甲基汞摄入量后，我们确定肥胖是否影响美国非怀孕成人（≥20岁）和儿童（2-19岁）的血汞水平，其中大部分是甲基汞。方法我们完成了国家健康和营养检查调查（NHANES）的二次数据分析（2007-2010）针对在采集血液进行汞分析的 24 小时内食用鱼类/贝类的参与者。加权最小二乘回归模型将血汞水平（因变量）与过去 24 小时内食用的鱼类的甲基汞暴露量 (μg)、体重指数 (BMI)（成人）、BMIz 分数（儿童）和其他混杂因素相关联。结果在调整后的模型中，血汞水平与成人 BMI 呈负相关 [β，95% 置信区间 (CI)=−0.54 (−0.90， −0.18)]。对于儿童，血汞水平与BMIz分数呈负相关，但趋势并不显着[β (95% CI)=-0.016 (-0.066, 0.035)]。当肥胖成人或儿童与超重/正常体重的人相比时，肥胖成人的血汞平均低22%（95% CI：-33%，-8.2%），而肥胖儿童的血汞没有显着差异[β（95% CI）=-1.7%（-31%，+39%）]。结论在调整甲基汞暴露的主要（如果不是唯一的）外源来源（通过鱼类/贝类）后摄入量）和其他混杂因素，我们的结果支持随着体重指数（成人）的增加，甲基汞的代谢、分布或排泄可能发生变化。
BackgroundIn animal studies obesity is associated with higher blood and tissue mercury concentrations; however human studies are lacking. Although the mechanism underlying this association is uncertain, obesity may alter the metabolism and distribution of methylmercury.ObjectivesWe determined whether obesity influenced blood mercury levels, the majority of which was methylmercury, for U.S. non-pregnant adults (≥20 years) and children (2–19 years) after controlling for methylmercury intake through fish and shellfish consumption, and other confounders.MethodsWe completed secondary data analysis of the National Health and Nutrition Examination Survey (NHANES) (2007–2010) for participants who consumed fish/shellfish within 24 h of blood collection for mercury analysis. Weighted least squares regression models related blood mercury levels (the dependent variable) to methylmercury exposure (μg) from fish consumed in the previous 24 h, body mass index (BMI) (for adults), BMIz-scores (for children), and other confounders.ResultsIn adjusted models, blood mercury levels were inversely correlated with BMI for adults [β, 95% confidence interval (CI)=−0.54 (−0.90, −0.18)]. For children, blood mercury levels were inversely correlated with BMIz-scores but the trend was not significant [β (95% CI)=−0.016 (−0.066, 0.035)]. When obese adults or children were compared with those who were overweight/normal weight, blood mercury averaged 22% lower for obese adults (95% CI: −33%, −8.2%), while blood mercury did not differ significantly for obese children [β (95% CI)=−1.7% (−31%, +39%)].ConclusionsAfter adjusting for the main, if not exclusive, exogenous source of methylmercury exposure (through fish/shellfish intake) and other confounders, our results support potential changes in the metabolism, distribution or excretion of methylmercury with increasing BMI (for adults).