A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media.
A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media.
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用于水性 19F MRI 造影剂的高氟化亲水分子。
DOI：
10.1155/2018/1693513
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发表时间：
2018
影响因子：
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通讯作者：
Annapragada,AnanthV
中科院分区：
文献类型：
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作者：
Tanifum,EricA;Devkota,Laxman;Ngwa,Conelius;Badachhape,AndrewA;Ghaghada,KetanB;Romero,Jonathan;Pautler,RobiaG;Annapragada,AnanthV
氟-19（19 F）磁共振成像（MRI）具有广泛的体内应用潜力，但由于外源性探针配方缺乏灵活性而受到限制。大多数19 F MRI探头由全氟化碳（PFC）或全氟聚醚（PFPE）组成，其固有特性限制了配方选择。亲水性有机氟分子可以在配方选择中提供更大的灵活性。我们在此报道了一种高度氟化的亲水性有机氟，ET 1084，其具有约24 wt. %19F含量。其溶于水和水性缓冲液中，得到含有≥8 M19 F的溶液。在9.4T下采用10分钟多层多回波（MSME）扫描序列进行的19 F MRI体模研究显示，信噪比（SNR）随分子浓度的增加呈线性增加，检测限为5 mM。初步的细胞毒性和遗传毒性评估表明，它在高达20 mM的浓度下是安全的。
Fluorine‐19 (19F) magnetic resonance imaging (MRI) has the potential for a wide range ofin vivoapplications but is limited by lack of flexibility in exogenous probe formulation. Most19F MRI probes are composed of perfluorocarbons (PFCs) or perfluoropolyethers (PFPEs) with intrinsic properties which limit formulation options. Hydrophilic organofluorine molecules can provide more flexibility in formulation options. We report herein a hyperfluorinated hydrophilic organoflourine,ET1084, with ∼24 wt. %19F content. It dissolves in water and aqueous buffers to give solutions with ≥8 M19F.19F MRI phantom studies at 9.4T employing a 10‐minute multislice multiecho (MSME) scan sequence show a linear increase in signal‐to‐noise ratio (SNR) with increasing concentrations of the molecule and a detection limit of 5 mM. Preliminary cytotoxicity and genotoxicity assessments suggest it is safe at concentrations of up to 20 mM.