Scaling properties of cell and organelle size
Scaling properties of cell and organelle size
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DOI：
10.4161/org.6.2.11464
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发表时间：
2010-04-01
期刊：
影响因子：
2.3
通讯作者：
Marshall, Wallace F.
中科院分区：
文献类型：
--
作者：
Chan, Yee-Hung M.;Marshall, Wallace F.
如何控制大小是生物学中的一个基本问题。在这篇评论中，我们讨论了使用的缩放关系，例如，幂律的形式y成比例的x（阿尔法）-提供一个框架的大小测量的比较和解释。这种分析可以说明观察到的趋势背后的生物学和物理学原理，正如已经提出的代谢率或肢体结构对生物体质量的异速生长依赖性。在更小的长度尺度上测量尺寸的技术不断改进，导致更多关于细胞和细胞器尺寸控制的数据。预计这些结构的尺寸缩放会影响生长模式、功能能力和细胞内转运。此外，细胞器，如细胞核，线粒体和内质网显示出广泛变化的形态，影响其缩放特性。我们提供了这些问题的简要总结，为个人的细胞器，并结束了讨论如何应用这一概念，以更好地了解在细胞环境中的大小控制的机制。
How size is controlled is a fundamental question in biology. In this review, we discuss the use of scaling relationships-for example, power laws of the form y proportional to x(alpha)-to provide a framework for comparison and interpretation of size measurements. Such analysis can illustrate the biological and physical principles underlying observed trends, as has been proposed for the allometric dependence of metabolic rate or limb structure on organism mass. Techniques for measuring size at smaller length-scales continue to improve, leading to more data on the control of size in cells and organelles. Size scaling of these structures is expected to influence growth patterns, functional capacity and intracellular transport. Furthermore, organelles such as the nucleus, mitochondria and endoplasmic reticulum show widely varying morphologies that affect their scaling properties. We provide brief summaries of these issues for individual organelles, and conclude with a discussion on how to apply this concept to better understand the mechanisms of size control in the cellular environment.