Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice.
Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice.
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DOI：
10.1371/journal.pone.0015623
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发表时间：
2010-12-22
期刊：
影响因子：
3.7
通讯作者：
Cho MH
中科院分区：
文献类型：
--
作者：
Yu KN;Minai-Tehrani A;Chang SH;Hwang SK;Hong SH;Kim JE;Shin JY;Park SJ;Kim JH;Kwon JT;Jiang HL;Kang B;Kim D;Chae CH;Lee KH;Yoon TJ;Beck GR;Cho MH
转移到肺部可能是乳腺癌相关发病率的最后一步。传统的治疗方法，如化疗和手术，在一定程度上是成功的，然而，与转移相关的乳腺癌发病率仍然很高。因此，需要一种新的方法来预防乳腺癌的转移。以慢病毒为基础的小发夹骨桥蛋白气雾剂每周给乳腺癌小鼠两次，持续1或2个月，使用仅鼻部吸入系统。用近红外成像和多种分子技术评价了小发夹骨桥蛋白对乳腺癌肺转移的影响。在我们的小鼠乳腺癌模型中，气雾剂传递的小发夹骨桥蛋白显著降低了骨桥蛋白的表达水平，并改变了几个重要的转移相关蛋白的表达。气雾剂传递的小发夹骨桥蛋白阻止了乳腺癌的转移。我们的结果表明，非侵袭性靶向肺骨桥蛋白或其他与肿瘤转移相关的特异性基因可以作为治疗转移性上皮性肿瘤的有效治疗方案。
Metastasis to the lung may be the final step in the breast cancer-related morbidity. Conventional therapies such as chemotherapy and surgery are somewhat successful, however, metastasis-related breast cancer morbidity remains high. Thus, a novel approach to prevent breast tumor metastasis is needed. Aerosol of lentivirus-based small hairpin osteopontin was delivered into mice with breast cancer twice a week for 1 or 2 months using a nose-only inhalation system. The effects of small hairpin osteopontin on breast cancer metastasis to the lung were evaluated using near infrared imaging as well as diverse molecular techniques. Aerosol-delivered small hairpin osteopontin significantly decreased the expression level of osteopontin and altered the expression of several important metastasis-related proteins in our murine breast cancer model. Aerosol-delivered small hairpin osteopontin blocked breast cancer metastasis. Our results showed that noninvasive targeting of pulmonary osteopontin or other specific genes responsible for cancer metastasis could be used as an effective therapeutic regimen for the treatment of metastatic epithelial tumors.
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影响因子：
11.2
作者：
Kim, HW;Park, IK;Cho, MH
通讯作者：
Cho, MH
影响因子：
12.4
作者：
Gautam, A;Densmore, CL;Waldrep, JC
通讯作者：
Waldrep, JC
DOI：
10.1164/rccm.200810-1553oc
发表时间：
2009-06-15
影响因子：
24.7
作者：
Hwang, Soon-Kyung;Lim, Hwang-Tae;Cho, Myung-Haing
通讯作者：
Cho, Myung-Haing
人源化抗骨桥蛋白抗体在体内抑制乳腺癌生长和转移
影响因子：
5.8
作者：
Dai, Jianxin;Li, Bohua;Guo, Yajun
通讯作者：
Guo, Yajun
影响因子：
5.1
作者：
Goula, D;Becker, N;Demeneix, BA
通讯作者：
Demeneix, BA