Weight loss and diabetes are new risk factors for the development of invasive aspergillosis infection in non-immunocompromized humans.
Weight loss and diabetes are new risk factors for the development of invasive aspergillosis infection in non-immunocompromized humans.
复制标题
DOI：
10.4172/clinical-practice.1000125
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Tayek, John A
中科院分区：
文献类型：
--
作者：
Ghanaat, Farhad;Tayek, John A
曲霉病的明确危险因素包括HIV、癌症、近期皮质类固醇（强的松）治疗、化疗或胸外科手术。未确定的风险因素可能包括体重减轻和糖尿病史。在加州大学洛杉矶分校海港医学中心，通过20年期间（1992-2012）的出院诊断，回顾性确定了23例无IA经典风险因素的患者。没有一个已知的风险因素是侵袭性脑膜炎（IA）。66%的IA患者（23例中的15例）有体重减轻史。体重减轻范围为3.3磅至43磅。在体重减轻的患者中，平均减轻为22±3 lbs（平均值±SEM）。在这一小组IA患者中，23例患者中有8例（34%）出现糖尿病，显著高于100例严重脓毒症患者中19%的糖尿病发病率（p
Well-established risk factors for aspergillosis include HIV, cancer, recent corticosteroid (prednisone) therapy, chemotherapy, or thoracic surgery. Non-established risk factors may include weight loss and a history of diabetes. Twenty-three patients without the classical risk factors for IA were identified retrospectively at Harbor UCLA Medical Center by discharge diagnosis over a 20 year period (1992-2012). None of the well-known risk factors are for Invasive Apergillious (IA). A history of weight loss was seen in 66% of the patients with IA (15 of 23). The weight loss ranged from 3.3 lbs to 43 lbs. In patients with weight loss the average loss was 22±3 lbs (mean±SEM). In this small group of patients with IA, diabetes was seen in 8 of the 23 (34%), which is significantly higher than the 19% incidence of diabetes seen in 100 patients with severe sepsis (p