Relationship between structure of benzimidazole derivatives and inhibitory activity on vaccinia virus multiplication.
Relationship between structure of benzimidazole derivatives and inhibitory activity on vaccinia virus multiplication.
复制标题
苯并咪唑衍生物的结构与痘苗病毒增殖抑制活性的关系。
DOI：
10.1016/0042-6822(57)90032-6
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发表时间：
1957
期刊：
影响因子：
3.7
通讯作者：
John R. Overman
中科院分区：
文献类型：
--
作者：
Igor Tamm;John R. Overman
现有证据表明，牛痘病毒中存在的核酸是脱氧核糖核酸（DNA），而流感病毒中存在的核酸是核糖核酸（RNA）。这种差异需要对这些试剂在可能特异性影响核酸生物合成的化合物存在下的增殖进行比较生化研究。由于最近对痘苗病毒在绒毛尿囊膜中体外增殖的表征，使得在相同实验条件下研究痘苗病毒和流感病毒的增殖成为可能。前面已描述了该系统中流感病毒增殖的动力学。研究了选定的苯并咪唑衍生物对牛痘病毒增殖的抑制作用。化合物的结构对其活性有显着影响。此外，对于某些衍生物，结构和抑制活性之间的关系与先前用相同化合物和乙型流感病毒建立的关系显着不同。氯化苯并咪唑中核糖atN-1的取代未能增强对痘苗病毒增殖的抑制活性，尽管先前表明这种结构的改变大大增强了对流感病毒增殖的抑制作用。讨论了这一发现的含义与两种病毒中存在的核酸类型的关系。
Available evidence indicates that nucleic acid present in vaccinia virus is deoxyribonucleic acid (DNA), whereas that present in influenza virus is ribonucleic acid (RNA). This difference invites comparative biochemical studies of the multiplication of these agents in the presence of chemical compounds which may specifically affect nucleic acid biosynthesis. Study of the multiplication of vaccinia and influenza viruses under the same experimental conditions has become possible as the result of the recent characterization of the multiplication of vaccinia virus in the chorioallantoic membranein vitro. Kinetics of influenza virus multiplication in this system has been described earlier.The inhibitory effect of selected benzimidazole derivatives on the multiplication of vaccinia virus was studied. The structure of compounds had a marked effect on their activity. Furthermore, with certain derivatives the relationships between structure and inhibitory activity differed markedly from those established previously with the same compounds and influenza B virus. Substitution of ribose atN-1 in chlorinated benzimidazoles failed to enhance the inhibitory activity on the multiplication of vaccinia virus, although it was shown previously that such an alteration in structure greatly increased the inhibitory effect on influenza virus multiplication. The implications of this finding are discussed in relation to the type of nucleic acid present in each of the two viruses.