LONGITUDINAL AND CROSS-SECTIONAL ESTIMATES OF PULMONARY-FUNCTION DECLINE IN NEVER-SMOKING ADULTS
LONGITUDINAL AND CROSS-SECTIONAL ESTIMATES OF PULMONARY-FUNCTION DECLINE IN NEVER-SMOKING ADULTS
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DOI：
10.1093/oxfordjournals.aje.a115710
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发表时间：
1990-10-01
影响因子：
5
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
--
作者：
WARE, JH;DOCKERY, DW;SPEIZER, FE
本文介绍了对定期检查的队列研究中重复测量的同时进行横断面和纵向分析的方法，然后用这些方法描述了1974年至1983年在马萨诸塞州的沃特敦进行的六城研究中不吸烟者肺功能水平与年龄有关的变化;田纳西州的金斯顿和哈里曼;密苏里州的圣路易斯;俄亥俄州的斯图本维尔;威斯康星州的波蒂奇;以及堪萨斯的托皮卡。这些受试者最初年龄在25-74岁之间，每隔3年进行3次检查。个体的损失率随着年龄的增长比横断面模型预测的要快。例如，对于身高1.75 m的男性，横截面模型预测FEV 1的年损失率从25岁时的23.7 ml/yr增加到75岁时的39.0 ml/yr，而纵向模型给出的损失率从25岁时的12.9 ml/yr增加到75岁时的58.2 ml/yr。这些结果与其他比较肺功能丧失的纵向和横截面估计的研究结果形成对比。
This paper describes methods for simultaneous cross-sectional and longitudinal analysis of repeated measurements obtained in cohort studies with regular examination schedules, then uses these methods to describe age-related changes in pulmonary function level among nonsmoking participants in the Six Cities Study, a longitudinal study of air pollution and respiratory health conducted between 1974 and 1983 in Watertown, Massachusetts; Kingston and Harriman, Tennessee; St. Louis, Missouri; Steubenville, Ohio; Portage, Wisconsin; and Topeka, Kansas. The subjects, initially aged 25-74, were examined on three occasions at 3-year intervals. Individuals rates of loss increased more rapidly with age than predicted from the cross-sectional model. For example, for a male of height 1.75 m, the cross-sectional model predicted an increase in the annual rate of loss of FEV1 from 23.7 ml/yr at age 25 to 39.0 ml/yr at age 75, while the longitudinal model gave rates of loss increasing from 12.9 ml/yr at age 25 to 58.2 ml/yr at age 75. These results contrast with those of other studies comparing longitudinal and cross-sectional estimates of pulmonary function loss.