Can new neurons replace memories lost?
Can new neurons replace memories lost?
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新的神经元可以替代丢失的记忆吗？
DOI：
10.1126/sageke.2003.49.pe35
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Shors,TraceyJ
中科院分区：
文献类型：
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作者：
Shors,TraceyJ
现在看来，新的神经元不仅在健康成人的大脑中产生，而且在阿尔茨海默病（AD）患者的大脑中也产生。尽管健康大脑中新神经元的功能尚不清楚，但有证据表明它们参与某些类型的记忆形成，并且通过学习经验，它们的存活率显着而持久地增强。有证据表明，神经发生，或者至少是未成熟神经元特有的蛋白质表达，发生在 AD 的晚期阶段，这表明它们的产生可能会在疾病过程的早期得到增强，从而避免如此多的神经元和记忆丧失。
It now appears that new neurons are produced not only in the healthy adult brain but also in the brains of patients with Alzheimer's disease (AD). Although the function of new neurons in the healthy brain is unknown, there is evidence that they are involved in certain types of memory formation and that their survival is enhanced dramatically and persistently by learning experiences. The evidence that neurogenesis, or at least the expression of proteins unique to immature neurons, occurs during the late stages of AD raises the possibility that their production could be enhanced earlier in the disease process before so many neurons and memories are lost.