Hippo: hungry, hungry for melanoma invasion.
Hippo: hungry, hungry for melanoma invasion.
复制标题
河马：饥饿，饥饿，黑色素入侵。
DOI：
10.1038/jid.2013.372
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Aplin,AndrewE
中科院分区：
文献类型：
--
作者：
Sanchez,IleineM;Aplin,AndrewE
黑色素瘤的侵袭性特性的获得与转移的高倾向有关，但其潜在的途径尚不清楚。Hippo通路在器官大小控制中起重要作用，在某些类型的肿瘤中是失调的。Nallet-Staubet等人2013年的研究“Hippo通路效应物YAP和TAZ在皮肤黑色素瘤中的侵袭性活性”首次深入分析了Hippo通路效应物YAP （yes-associated protein）和TAZ （Tafazzin）在人类黑色素细胞病变中的表达。重要的是，本研究结果表明YAP/TAZ水平与黑色素瘤细胞致瘤性和侵袭性之间存在因果关系。
The acquisition of invasive properties in melanoma is associated with a high proclivity for metastasis, but the underlying pathways are poorly characterized. The Hippo pathway has an important role in organ size control and is dysregulated in some type of tumors. The present study, “Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma” by Nallet-Staubet al., 2013, provides the first in-depth analysis of expression of the Hippo pathway effectors YAP (yes-associated protein) and TAZ (Tafazzin) in human melanocytic lesions. Importantly, results from this study demonstrate a causal relationship between YAP/TAZ levels and melanoma cell tumorigenicity and invasiveness.