Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral Hemorrhage
Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral Hemorrhage
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DOI：
10.1161/01.str.0000035283.34109.ea
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发表时间：
2002-11-01
期刊：
影响因子：
8.3
通讯作者：
Broderick, JP
中科院分区：
文献类型：
--
作者：
Gebel, JM;Jauch, EC;Broderick, JP
关于自发性脑内出血（ICH）和结果中近日成amaTomaTomal水肿之间的关系已知。这项研究的目的是确定绝对或相对水肿体积（水肿体积除外，还可以预测过度急性自发ICH患者的死亡率或功能结果。我们假设增加基线相对水肿量与功能性较差的可能性相关。方法是对142例自发ICH患者的血肿生长的前瞻性，基于人群的研究的次要分析。患者在发病的3小时内成像，然后在我和20小时后成像。我们的主要分析排除了抗凝使用（n = 7）的患者，其潜在动脉瘤/血管畸形（n = 9），创伤（n = 1），不完整数据（n = 20），infratentorial iCh（n = 17），静脉内伸展（n = 38），没有同意（n = 2）。我们分析了基线水肿量或其他临床/放射学变量之间是否存在关联，而修改后的Rankin量表得分> 2或30天死亡率。次级分析使用20小时CT扫描数据，所有尖顶ICH患者和12周的Barthel指数评分
Background and Purpose-Little is known about the relationship between perihematomal edema in spontaneous intracerebral hemorrhage (ICH) and outcome. The purpose of this study was to determine whether absolute or relative edema volume (edema volume divided by hematoma volume) predicts mortality or functional outcome in patients with hyperacute spontaneous ICH. We hypothesized that increasing baseline relative edema volume is associated with greater probability of poor functional outcome.Methods-This was a secondary analysis of a prospective, population-based study of hematoma growth in 142 patients with spontaneous ICH. Patients were imaged within 3 hours of onset, then I and 20 hours later. Our primary analysis excluded patients with anticoagulant use (n=7), underlying aneurysm/vascular malformation (n=9), trauma (n=1), incomplete data (n=20), infratentorial ICH (n=17), intraventricular extension (n=38), and no consent (n=2). We analyzed whether associations existed between baseline edema volumes or other clinical/radiological variables and either 12-week modified Rankin Scale score >2 or 30-day mortality. Secondary analyses used 20-hour CT scan data, all patients with supratentorial ICH, and 12-week Barthel Index score