Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.
Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.
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DOI：
10.1111/imr.12119
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发表时间：
2013-11
影响因子：
8.7
通讯作者：
Cancelas JA
中科院分区：
文献类型：
--
作者：
Nayak RC;Chang KH;Vaitinadin NS;Cancelas JA
鸟苷三磷酸酶（GTPases）的Rho家族由Ras超家族的成员组成。它们是与gtp结合的分子，具有适度的内在gtp酶活性，可以在特定的鸟嘌呤核苷酸交换因子的激活/定位时加速。这个家族的成员作为分子开关，需要协调细胞骨架重排，这在哺乳动物干细胞的一系列特殊功能中是至关重要的。这些功能包括自我更新、粘附和迁移。小鼠基因靶向研究提供了令人信服的证据，证明Rho GTPase家族的个体成员和假定的上游和下游介质在干细胞特异性功能中不可或缺和可有可无的作用。Rho gtpase和相关信号通路的作用已经在哺乳动物造血干细胞（hsc）中得到证实，新的信号通路和hsc独有的意想不到的功能已经被发现和解剖。这篇综述总结了我们目前对Rho家族gtpase通过细胞骨架介导的信号通路对HSC和祖细胞活性的作用的理解，提供了调控哺乳动物干细胞自我更新、粘附和迁移的相关信号通路的见解。
The Rho family of guanosine triphosphatases (GTPases) is composed of members of the Ras superfamily of proteins. They are GTP-bound molecules with a modest intrinsic GTPase activity that can be accelerated upon activation/localization of specialized guanine nucleotide exchange factors. Members of this family act as molecular switches and are required for coordinated cytoskeletal rearrangements that are crucial in a set of specialized functions of mammalian stem cells. These functions include self-renewal, adhesion, and migration. Mouse gene-targeting studies have provided convincing evidence of the indispensable and dispensable roles of individual members of the Rho GTPase family and the putative upstream and downstream mediators in stem cell-specific functions. The role of Rho GTPases and related signaling pathways previously seen in other cell types and organisms have been confirmed in mammalian hematopoietic stem cells (HSCs), and new signaling pathways and unexpected functions unique to HSCs have been identified and dissected. This review summarizes our current understanding of the role of Rho family of GTPases on HSC and progenitor activity through cytoskeleton-mediated signaling pathways, providing insight on relevant signaling pathways that regulate mammalian stem cell self-renewal, adhesion, and migration.
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影响因子：
20.3
作者：
Beekman, Renee;Valkhof, Marijke G.;Touw, Ivo P.
通讯作者：
Touw, Ivo P.
影响因子：
9.2
作者：
Baird, D;Feng, QY;Cerione, RA
通讯作者：
Cerione, RA
影响因子：
7.5
作者：
Chesarone MA;Goode BL
通讯作者：
Goode BL
影响因子：
82.9
作者：
Cancelas, JA;Lee, AW;Williams, DA
通讯作者：
Williams, DA
DOI：
10.1083/jcb.141.5.1147
发表时间：
1998-06-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Allen WE;Zicha D;Ridley AJ;Jones GE
通讯作者：
Jones GE