Predictors of neuropsychological performance in HIV positive women
Predictors of neuropsychological performance in HIV positive women
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DOI：
10.1076/jcen.23.2.149.1211
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发表时间：
2001-01-01
影响因子：
2.2
通讯作者：
Wyatt, GE
中科院分区：
文献类型：
--
作者：
Durvasula, RS;Miller, EN;Wyatt, GE
本研究探讨预测神经心理学（NP）的表现在社区样本的237艾滋病毒血清阳性和血清阴性的妇女。与描述男性HIV感染NP后遗症的文献一致，我们预计HIV状态将预测NP在评估言语记忆、精神速度和运动速度的测试中表现较差。多重回归分析测试艾滋病毒血清状态和NP性能之间的关联，并控制预测因素，包括年龄，种族，教育，心理困扰，药物和酒精的使用表明，艾滋病毒血清状态与减缓的心理速度。具体而言，艾滋病诊断和艾滋病毒血清阳性预测较差的性能测试的心理速度相对于艾滋病毒血清阴性。与预期相反，HIV血清状态与运动速度或非文字记忆表现之间没有关系。教育，种族，抑郁困扰，最近暴露于药物的毒理学指标，和酒精的使用也与NP性能。鉴于艾滋病毒血清反应阳性和阴性样本在一些人口统计学和药物使用变量上存在差异，还进行了第二系列分析，审查了一个参与者子集（在所有关键人口统计学因素上相匹配），并且在过去一年中没有非法药物使用。这些分析的结果与对全部样本的分析结果相似，艾滋病诊断和艾滋病毒血清阳性预示着精神病的减缓。迄今为止，很少有工作描述了NP后遗症的艾滋病毒感染的妇女已经进行。这项研究提供了一个主要是非注射药物使用社区样本的妇女艾滋病毒/艾滋病的NP影响的第一个描述。
This study examines predictors of neuropsychological (NP) performance in a community sample of 237 HIV seropositive and seronegative women. Consistent with literature describing the NP sequelae of HIV infection in men, we expected that HIV status would predict poorer NP performance on tests assessing verbal memory, psychomotor speed and motor speed. Multiple regression analyses testing the association between HIV serostatus and NP performance and controlling for predictors including age, ethnicity, education, psychological distress, and drug and alcohol use indicated that HIV serostatus was associated with slowed psychomotor speed. Specifically, AIDS diagnosis and HIV seropositivity predicted poorer performance on tests of psychomotor speed relative to HIV seronegatives. Contrary to expectations, no relationship between HIV serostatus and either motor speed or verbal memory performance emerged. Education, ethnicity, depressive distress, recent exposure to drugs as indexed by toxicology, and alcohol use were also associated with NP performance. Given that the HIV seropositive and seronegative samples differed on a number of demographic and drug use variables, a second series of analyses examining a subset of participants (matched on all key demographic factors) and with no illicit drug use during the past year was also conducted. Results of these analyses were similar to those obtained for the full sample, with AIDS diagnosis and HIV seropositivity predicting psychomotor slowing. To date, little work describing the NP sequelae of HIV infection in women has been conducted. This study provides one of the first descriptions of the NP effects of HIV/AIDS in a largely non-injection drug using community sample of women.