Integrating Myc and TGF-β signalling in cell-cycle control
Integrating Myc and TGF-β signalling in cell-cycle control
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DOI：
10.1038/35074634
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发表时间：
2001-05-01
影响因子：
21.3
通讯作者：
Amati, B
中科院分区：
文献类型：
--
作者：
Amati, B
细胞周期抑制因子p15(INK4b)的表达受Myc癌蛋白的抑制，并受转化生长因子-β(TGF-β)的诱导。转录因子MiZ-1激活Ink4b启动子，并与Myc和转化生长因子β激活的Smad蛋白相互作用。因此，MIZ-1是细胞周期控制中这些拮抗信号的汇聚点。
Expression of the cell cycle inhibitor p15(INK4b) is suppressed by the Myc oncoprotein and induced by transforming growth factor-beta (TGF-beta). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-beta -activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.