Improved Carbohydrate Recognition in Water with an Electrostatically Enhanced β-Peptide Bundle
Improved Carbohydrate Recognition in Water with an Electrostatically Enhanced β-Peptide Bundle
复制标题
DOI：
10.1021/acs.orglett.5b02187
复制
发表时间：
2015-10-02
期刊：
影响因子：
5.2
通讯作者：
Schepartz, Alanna
中科院分区：
文献类型：
--
作者：
Melicher, Michael S.;Walker, Allison S.;Schepartz, Alanna
低聚糖甚至是单糖在水溶液中的选择性募集是一个尚未解决的分子识别问题。以结构为导向的静电重新设计显著提高了在中性水溶液中β-肽“硼-束”与单糖的亲和力。在水中对果糖(663M-1)的亲和力应使其能够被招募到束表面进行选择性催化，未来的工作将集中在这一方向。
The selective recruitment of oligosaccharides, or even simple sugars, in water solvent is an unsolved molecular recognition problem. Structure-guided, electrostatic redesign led to a significant increase in the affinity of a beta-peptide "borono-bundle" for simple sugars in neutral aqueous solution. The affinity for fructose (663 M-1) in water should allow its recruitment to the bundle surface for selective catalysis, and future work will focus in this direction.