Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment
Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment
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用于开发新型特应性皮炎治疗的可见光光学相干断层扫描平台
DOI：
10.1117/12.2647563
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Revin D
中科院分区：
文献类型：
--
作者：
Revin D
特应性皮炎是一种慢性、复发性炎症性皮肤病，是世界上发病率最高的疾病之一。人们普遍认为这是由角质层提供的皮肤屏障层的缺陷引起的。角质层厚度决定了局部治疗的吸收率，并可能与其防止过敏原渗透的屏障功能相关。在这里，我们展示了一个自由空间，便携式傅立叶域可见光光学相干断层扫描（OCT）系统，研究角质层厚度（5-15 μm）在非手掌人类皮肤。我们使用超连续谱激光源，针对500-700 nm范围内的发射进行了优化，并在组织中实现了~ 1 μm的轴向分辨率（角质层的折射率n = 1.55）。我们的系统在125 kHz的A扫描速率下具有约-85 dB的灵敏度，并且在皮肤上具有约1 mW的光功率。获得了来自各种人类皮肤部位的高质量B扫描，其中清楚分辨的角质层呈现为低回声暗层，类似于使用传统OCT系统在手掌皮肤中发现的。
Atopic dermatitis is a chronic, relapsing inflammatory skin disease, which has one of the highest prevalence rates in the world. It is widely believed to be driven by deficiencies in the skin barrier layer, which is provided by the stratum corneum. The stratum corneum thickness determines the absorption rate of topical treatments and may correlate with its barrier function of preventing allergen penetration. Here we demonstrate a free-space, portable Fourier domain visible-light optical coherence tomography (OCT) system to study the stratum corneum thickness (5-15 μm typically) in non-palmar human skin. We use a supercontinuum laser source, optimized for emission in the 500-700 nm range and achieve axial resolution of ~ 1 μm in tissue (for the refractive index n = 1.55 of the stratum corneum). Our system has ~ -85 dB sensitivity at an A-scan rate of 125 kHz and about 1 mW of optical power onto the skin. High-quality B-scans from various human skin sites are obtained, with a clearly resolved stratum corneum layer presenting as a hypoechogenic dark layer, similar to that found in palmar skin with traditional OCT systems.
特应性湿疹/皮炎综合征——一种复杂的遗传疾病，发现遗传因素的新进展。
影响因子：
12.4
作者：
H. Klüken;T. Wienker;T. Bieber
通讯作者：
T. Bieber