Functional neuroimaging biomarkers of resilience in major depressive disorder.
Functional neuroimaging biomarkers of resilience in major depressive disorder.
复制标题
DOI：
10.1097/yco.0000000000000662
复制
发表时间：
2021-01
影响因子：
6.9
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Fischer AS;Hagan KE;Gotlib IH
在这篇综述中，我们提供了一个概述的定义和决定因素的背景下，在重性抑郁症（MDD）的神经影像学研究。我们总结了新出现的文献功能神经影像学生物标志物的韧性在MDD和讨论其临床意义和未来的研究。MDD中的复原力的特征在于参与认知控制、情绪调节和奖励处理的脑网络内的激活和功能连接的可分离的概况。参与认知评价和情绪调节的额叶皮层脑区的激活增加是MDD高风险的弹性个体和具有良好病程的MDD个体的共同特征。此外，额-纹状体-边缘系统功能连接与弹性高风险个体的积极解释压力生活事件和抑郁个体对一线治疗的有利反应之间的显着关联表明，神经代偿性变化和经验依赖性可塑性是MDD弹性的基础。新兴的研究已经确定了假定的功能性神经影像学生物标志物的韧性在MDD。在动态环境和发展对MDD的影响的背景下，继续关注识别弹性的神经生物学基础，将促进我们对这种疾病的弹性的理解，并改善预防和治疗方法。
In this review we provide an overview of definitions and determinants of resilience in the context of neuroimaging research in Major Depressive Disorder (MDD). We summarize emerging literature on functional neuroimaging biomarkers of resilience in MDD and discuss their clinical relevance and implications for future research. Resilience in MDD is characterized by dissociable profiles of activation and functional connectivity within brain networks involved in cognitive control, emotion regulation, and reward processing. Increased activation of frontal cortical brain regions implicated in cognitive appraisal and emotion regulation is a common characteristic of resilient individuals at high risk for MDD and of individuals with MDD with a favorable illness course. Furthermore, significant associations between fronto-striato-limbic functional connectivity and both positively-interpreted stressful life events in resilient high-risk individuals and a favorable response to first-line treatments in depressed individuals suggest that neuro-compensatory changes and experience-dependent plasticity underlie resilience in MDD. Emerging research has identified putative functional neuroimaging biomarkers of resilience in MDD. A continued focus on identifying neurobiological underpinnings of resilience, in the context of dynamic environmental and developmental influences on MDD, will advance our understanding of resilience in this disorder and improve approaches to prevention and treatment.