Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats
Composition and evolution of the V2r vorneronasal receptor gene repertoire in mice and rats
复制标题
小鼠和大鼠 V2r 鼻鼻受体基因库的组成和进化
DOI：
10.1016/j.ygeno.2005.05.012
复制
发表时间：
2005-09-01
期刊：
影响因子：
4.4
通讯作者：
Zhang, JZ
中科院分区：
文献类型：
--
作者：
Yang, H;Shi, P;Zhang, JZ
信息素是由同种动物产生和检测的化学物质，以引起社会/性生理和行为反应，并且它们主要由陆生脊椎动物的犁鼻器（VNO）感知。两个大的G蛋白偶联受体超家族，V1 rs和V2 rs，已被确定为犁鼻感觉神经元中的信息素受体。基于对小鼠和大鼠基因组序列的计算分析，我们报告了V2 r基因库的第一个全球草案，由类似的200个基因和假基因组成。啮齿动物V2 rs受到快速的基因出生/死亡和加速的氨基酸替换，可能反映了信息素的物种特异性。脊椎动物V2 RS似乎起源于两次之前出现的VNO在祖先的四足动物，解释似乎不一致的意见之间的不同V2 RS。整个V2 r库的鉴定打开了对这组不同感觉受体的结构、功能和进化的基因组水平研究的大门。(c)2005年爱思唯尔公司All rights reserved.
Pheromones are chemicals produced and detected by conspecifics to elicit social/sexual physiological and behavioral responses, and they are perceived primarily by the vomeronasal organ (VNO) in terrestrial vertebrates. Two large superfamilies of G protein-coupled receptors, V1rs and V2rs, have been identified as pheromone receptors in vomeronasal sensory neurons. Based on a computational analysis of the mouse and rat genome sequences, we report the first global draft of the V2r gene repertoire, composed of similar to 200 genes and pseudogenes. Rodent V2rs are subject to rapid gene births/deaths and accelerated amino acid substitutions, likely reflecting the species-specific nature of pheromones. Vertebrate V2rs appear to have originated twice prior to the emergence of the VNO in ancestral tetrapods, explaining seemingly inconsistent observations among different V2rs. The identification of the entire V2r repertoire opens the door to genomic-level studies of the structure, function, and evolution of this diverse group of sensory receptors. (c) 2005 Elsevier Inc. All rights reserved.