Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
复制标题
DOI：
10.1021/ja9530681
复制
发表时间：
1996-03-20
影响因子：
15
通讯作者：
Boger, DL
中科院分区：
文献类型：
--
作者：
Cheng, S;Comer, DD;Boger, DL
描述了一种简单、通用和通用的方法，用于溶液阶段，在通用或通用模板上进行的化学库的并行合成，其允许制备每个单独成员的多毫克量。在序列的每个步骤中，通过简单的液/液或液/固萃取来去除反应物、未反应的起始原料、试剂及其副产物，以提供所需的高纯度(平均95%)的中间体和最终化合物，而不考虑反应产率，也不需要刻意的反应优化。
A simple, versatile, and general approach to the solution phase, parallel synthesis of chemical libraries conducted on a generalized or universal template, which allows the preparation of multi-milligram quantities of each individual member, is described. In each step of the sequence, the reactants, unreacted starting material, reagents and their byproducts are removed by simple liquid/liquid or liquid/solid extractions providing the desired intermediates and final compounds in high purities (95% average) irrespective of the reaction yields and without deliberate reaction optimization.