The Impact of Substance Use Disorder on COVID-19 Outcomes.

The Impact of Substance Use Disorder on COVID-19 Outcomes.
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药物使用障碍对19种结果的影响。

DOI:
10.1176/appi.ps.202000534
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发表时间:
2021-05-01
期刊:
Psychiatric services (Washington, D.C.)
影响因子:
--
通讯作者:
Raji MA
Raji MA
中科院分区:
其他
文献类型:
--
作者:
Baillargeon J;Polychronopoulou E;Kuo YF;Raji MA

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本研究的目的是考察物质使用障碍对确诊为新冠肺炎的成年患者住院风险、并发症和死亡率的影响。我们进行了一项与倾向评分(PS)匹配的双队列研究,利用TriNetX研究网络数据库的数据确定了2020年2月20日至2020年6月30日期间确诊的54,529名成年新冠肺炎患者(≥18岁)。我们的初步分析表明,物质使用障碍与住院(OR=1.84;95%CI=1.69,2.01)、使用呼吸机(OR=1.45;95%CI=1.22,1.72)和死亡率(OR=1.30;95%CI=1.09,1.56)的风险增加有关。我们的研究结果表明,新冠肺炎中有物质使用障碍的患者发生不良结果的风险增加。最终模型中ORs的减弱表明,观察到的风险可能部分由药物相关的呼吸系统和心血管疾病介导。
The goal of this study was to examine the impact of substance use disorder on the risk of hospitalization, complications, and mortality in adult patients diagnosed with COVID-19 We conducted a propensity score (PS) matched double cohort study using data from the TriNetX Research Network database to identify 54,529 adult COVID-19 patients (≥18 years) diagnosed between February 20, 2020 and June 30, 2020. Our primary analysis—PS matched on demographic characteristics, diabetes, and obesity—showed that substance use disorder was associated with an increased risk of hospitalization (OR=1.84; 95% CI=1.69, 2.01), ventilator use (OR=1.45; 95% CI=1.22, 1.72) and mortality (OR=1.30; 95% CI=1.09, 1.56). Our findings suggest that COVID-19 patients with substance use disorders are at increased risk for adverse outcomes. The attenuation of ORs in the final model suggests that the observed risks may be partially mediated by drug-related respiratory and cardiovascular disease.
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