Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone.
Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone.
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DOI：
10.1038/srep13244
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发表时间：
2015-08-18
影响因子：
4.6
通讯作者：
Najmudin Z
中科院分区：
文献类型：
--
作者：
Cole JM;Wood JC;Lopes NC;Poder K;Abel RL;Alatabi S;Bryant JS;Jin A;Kneip S;Mecseki K;Symes DR;Mangles SP;Najmudin Z
利用激光韦克菲尔德加速电子产生的电子感应加速器振荡，研制了一台明亮的μ m硬同步辐射X射线源（临界能量Ecrit > 30 keV）。通过对人类股骨松质骨样本进行微计算机断层扫描，可以实现分辨率低于50 μm的全三维重建，证明了该源用于医学成像的潜力。使用1 cm长的韦克菲尔德加速器意味着束线的长度（不包括激光器）由X射线成像距离而不是电子加速距离决定。该光源具有高峰亮度，这使得每个图像都可以用一次曝光记录，并减少了完整断层扫描所需的时间。这些特性使其成为许多断层成像应用的有趣的实验室源。
A bright μm-sized source of hard synchrotron x-rays (critical energy Ecrit > 30 keV) based on the betatron oscillations of laser wakefield accelerated electrons has been developed. The potential of this source for medical imaging was demonstrated by performing micro-computed tomography of a human femoral trabecular bone sample, allowing full 3D reconstruction to a resolution below 50 μm. The use of a 1 cm long wakefield accelerator means that the length of the beamline (excluding the laser) is dominated by the x-ray imaging distances rather than the electron acceleration distances. The source possesses high peak brightness, which allows each image to be recorded with a single exposure and reduces the time required for a full tomographic scan. These properties make this an interesting laboratory source for many tomographic imaging applications.