Paediatric HIV-1 infection
Paediatric HIV-1 infection
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DOI：
10.1016/s0140-6736(99)90249-0
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发表时间：
1999-09-01
期刊：
影响因子：
168.9
通讯作者：
Mofenson, LM
中科院分区：
文献类型：
--
作者：
Burns, DN;Mofenson, LM
儿童母婴传播HIV-1感染的防治进展对儿童产生了巨大的影响，即使在发达国家，围产期传播也没有消除这种疾病在儿童中的发病和进展。一些欧洲和北美的艾滋病病毒感染孕妇。广泛实施的妇女仍然没有提供或拒绝艾滋病毒检测，其他三部分齐多夫定预防，增加了没有得到产前护理，在少数情况下，齐多夫定选择剖腹产的艾滋病毒感染的妇女，预防失败。12目前在这些国家进行的研究是使用联合抗逆转录病毒疗法，重点是如何增加三部分儿童的益处，暂时与齐多夫定疗法下降有关，并为儿童艾滋病提供替代方案，提高存活率1。2.3直到艾滋病毒传播率低至1 -2%的晚期才确定HIV-1状态的围产期妇女已经怀孕或分娩。据报道，在发展中国家，HIV-1血清阳性率和选择性剖腹产联合抗病毒预防。3-5不幸的是，这些进步在发达国家、发展中国家的成本和复杂性方面几乎没有影响。联合国艾滋病规划署估计，每天充分齐多夫定方案的适用性有限。在1500名15岁以下儿童中进行的研究成为这些国家抗逆转录病毒感染的重点，主要是通过母婴传播。6个疗程和非抗逆转录病毒干预措施。
Advances in the prevention and treatment of paediatric Mother-to-child transmission HIV-l infection have had a huge impact on the Even in developed countries perinatal transmission has incidence and progression of this disease in children in not been eliminated. Some HIV-infected pregnant Europe and North America. Widespread implementation women are still not offered or decline HIV testing, others of three-part zidovudine prophylaxis,’ an increase in receive no prenatal care, and in a few cases zidovudine elective caesarean delivery of HIV-infected women, and prophylaxis fails. 12 Current studies in these countries are the use of combination antiretroviral regimens in focusing on ways to augment the benefit of the three-part children have been temporally associated with a decline zidovudine regimen and to provide alternatives for in paediatric AIDS and increased surviva1. 2, 3 Perinatal women whose HIV-l status is not identified until late in HIV transmission rates as low as l-2% have been pregnancy or at delivery. reported with the combination of antiviral prophylaxis In developing countries, where HIV-l seroprevalence and elective caesarean section. 3-5 among pregnant women is often many times higher than Unfortunately, these advances have had little impact in it is in developed countries, the cost and complexity of the developing world. UNAIDS estimates that every day the full zidovudine regimen limit applicability. Studies in sees 1500 children under 15 years of age become these countries have focused on abbreviated antiretroviral infected, largely by mother-to-child transmission. 6 regimens and non-antiretroviral interventions.