Computational tools for modeling electrical activity in cardiac tissue
Computational tools for modeling electrical activity in cardiac tissue
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DOI：
10.1016/j.jelectrocard.2003.09.017
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发表时间：
2003-01-01
影响因子：
1.3
通讯作者：
Leon, LJ
中科院分区：
文献类型：
--
作者：
Vigmond, EJ;Hughes, M;Leon, LJ
计算机模型提供了许多有吸引力的好处。然而，心脏组织的建模是计算昂贵的，由于几个物理约束，导致在大的时空区域上的精细时空离散化。在过去的15年里，我们的实验室一直在积极尝试开发新技术，使大规模的心脏模拟变得易于处理。本文介绍了我们小组开发的最新建模软件Carp（Cardiac arrhythmia research package）。它被设计为在共享内存和集群计算环境中运行。Carp的目标是通过遵循插件框架实现模块化和灵活性。这允许最新的模型和最有效的求解器被纳入，以及使运行时选择的技术。性能结果给出了一个大规模的模拟，利用了全面的膜离子电流的描述。
Computer models offer many attractive benefits. However, the modeling of cardiac tissue is computationally expensive due to several physical constraints which result in fine spatiotemporal discretization over large spatiotemporal regions. Our laboratory has been actively trying to develop new techniques to make large scale cardiac simulations tractable over the past 15 years. This paper describes the latest modeling software that our group has developed, called Carp (Cardiac arrhythmias research package). It is designed to run in both shared memory and clustered computing environments. Carp aims to be modular and flexible by following a plug-in framework. This allows the latest models and most efficient solvers to be incorporated as well as enabling run-time selection of techniques. Performance results are given for a large-scale simulation which utilized a comprehensive membrane ionic current description.