Stochastic elimination of cancer cells
Stochastic elimination of cancer cells
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DOI：
10.1098/rspb.2003.2483
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发表时间：
2003-10-07
影响因子：
4.7
通讯作者：
Iwasa, Y
中科院分区：
文献类型：
--
作者：
Michor, F;Nowak, MA;Iwasa, Y
多细胞生物的组织由干细胞和分化细胞组成。干细胞分裂产生新的干细胞或分化的细胞。分化的细胞分裂产生新的分化细胞。我们表明，这样的组织设计可以降低增加细胞净增殖率的突变的固定率。然而，它对中性突变的固定率没有影响。我们计算干细胞的最佳相对丰度，使产生癌细胞的速度降至最低。有一个干细胞分裂的关键部分，是随机消除(“洗出”)癌细胞所必需的。
Tissues of multicellular organisms consist of stem cells and differentiated cells. Stem cells divide to produce new stem cells or differentiated cells. Differentiated cells divide to produce new differentiated cells. We show that such a tissue design can reduce the rate of fixation of mutations that increase the net proliferation rate of cells. It has, however, no consequence for the rate of fixation of neutral mutations. We calculate the optimum relative abundance of stem cells that minimizes the rate of generating cancer cells. There is a critical fraction of stem cell divisions that is required for a stochastic elimination ('wash out') of cancer cells.