EVALUATION OF SYNERGISM OR ANTAGONISM FOR THE COMBINED ACTION OF ANTIVIRAL AGENTS
EVALUATION OF SYNERGISM OR ANTAGONISM FOR THE COMBINED ACTION OF ANTIVIRAL AGENTS
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DOI：
10.1016/0166-3542(90)90042-6
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发表时间：
1990-01-01
影响因子：
7.6
通讯作者：
SUHNEL, J
中科院分区：
文献类型：
--
作者：
SUHNEL, J
用于评价抗病毒药物联合作用的协同或拮抗作用的标准进行了严格的审查。等效线法是唯一普遍适用的方法，它不需要对剂量-反应曲线的形状进行任何假设。本文提出了一种基于微机的等效线法，它可以从少量的实验中构造出响应面和一组完整的等效线。这项工作的目的是采取一个步骤，标准化的定义，术语和抗病毒药物联合实验中的协同作用或拮抗作用的评价方法。
The criteria used for the evaluation of synergism or antagonism for the combined action of antiviral agents are critically reviewed. The isobole method is the only generally applicable approach which does not require any assumptions about the shape of dose-response curves. A microcomputer-based isobole method is proposed which constructs response surfaces and a complete set of isoboles in the dose range under study from a relatively small number of experiments. The objective of this work is to take a step towards standardization of definitions, terminology, and methods for the evaluation of synergism or antagonism in antiviral drug combination experiments.