Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry
Bio-active restorative materials with antibacterial effects: new dimension of innovation in restorative dentistry
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DOI：
10.4012/dmj.28.11
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Imazato, Satoshi
中科院分区：
文献类型：
--
作者：
Imazato, Satoshi
新时代的修复材料应具有“生物活性”，抗菌作用作为重要性能之一被凸显出来。为了获得具有抗菌效果的树脂基增塑剂，开发了一种抗菌单体MDPB。含有MDPB的底漆显示出空腔消毒效果，并且世界上第一个使用含有MDPB的底漆的抗菌粘合剂系统成功商业化。MDPB可潜在地应用于各种消毒剂，因为通过MDPB的聚合来固定抗菌组分使得固化树脂的机械性能不劣化，并且对它们的表面上的细菌生长表现出抑制效果。对于用于无创伤修复治疗的玻璃离子粘固剂，已尝试通过添加氯己定来提供抗菌活性的方法。加入1%的双醋酸氯己定是最佳的，可以提供适当的抗菌和物理性能，有效减少受影响和感染牙本质中的细菌。vivo.
Restorative materials in the new era should be "bio-active", and antibacterial effects are highlighted as one of the important properties. In order to achieve resin-based restoratives with antibacterial effects, an antibacterial monomer MDPB has been developed. The primer incorporating MDPB demonstrated cavity-disinfecting effects, and the world's first antibacterial adhesive system employing the MDPB-containing primer was Successfully commercialized. MDPB is potentially applicable to various restoratives since immobilization of the antibacterial component by polymerization of MDPB enables no deterioration in mechanical properties of cured resins and exhibition of inhibitory effects against bacterial growth oil their Surfaces. For glass-ionomer cements used for atraumatic restorative treatment, the approach to provide antibacterial activity has been attempted by addition of chlorhexidine. Incorporation of 1% chlorhexidine diacetate was found to be optimal to give appropriate antibacterial and physical properties, being effective to reduce the bacteria in affected and infected dentin in. vivo.