The effect of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.
The effect of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.
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DOI：
10.26355/eurrev_202111_27096
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发表时间：
2021-11
影响因子：
3.3
通讯作者：
B. Jia;C-G Wang;Hao A Chen;X.-B. Zhou;K. Qian;Chii-Ming Chen;L-X Xu;J-L Fu
中科院分区：
文献类型：
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作者：
B. Jia;C-G Wang;Hao A Chen;X.-B. Zhou;K. Qian;Chii-Ming Chen;L-X Xu;J-L Fu
胞浆动力蛋白是一种多亚基复合体，包括胞浆动力蛋白1(Dynein 1)和胞浆动力蛋白2(Dynein 2)。它参与各种基本的细胞过程，包括核迁移、有丝分裂纺锤体的组织、有丝分裂过程中的染色体分离以及许多细胞内细胞器的位置和功能。视网膜光感受器细胞是终末分化的神经元，一旦丢失，就不能再生和替换。因此，研究它们的发展对于促进光感受器疾病治疗的产生和改进是至关重要的。感光细胞的外节(OS)是一种特殊的感觉纤毛。越来越多的研究表明，胞浆动力蛋白在视网膜光感受器细胞的发育过程中起着至关重要的作用。到目前为止，人们已经对动力蛋白在细胞中的各种功能做了大量的研究，并有了非常详细的了解。然而，动力蛋白在视网膜光感受器细胞中的作用还没有详细的总结。本文综述了细胞质动力蛋白在视网膜光感受器细胞发育和功能维持中的作用及其机制。
Cytoplasmic dynein is a multi-subunit complex that includes cytoplasmic dynein-1 (dynein1) and cytoplasmic dynein-2 (dynein2). It participates in various basic cellular processes, including nuclear migration, mitotic spindle organization, chromosome separation during mitosis, and the location and function of numerous intracellular organelles. Retinal photoreceptor cells are terminally differentiated neurons that cannot regenerate and cannot be replaced once lost. It is thus crucial to study their development to facilitate the generation and improvement of photoreceptor disease treatments. The outer segment (OS) of photoreceptor cells is a specific sensory cilium. An increasing number of studies have shown that cytoplasmic dynein plays an essential role in the development of retinal photoreceptor cells. To date, people have done a lot of studies on the various functions of dynein in cells and have a very detailed understanding. However, the role of dynein in retinal photoreceptor cells has not been summarized in detail. This article summarizes the currently available knowledge relating to the effects and mechanisms of cytoplasmic dynein on the development and functional maintenance of retinal photoreceptor cells.